The Journal of Endocrinology
A brain estrogen signal helped regulate bone mass in female mice
In experiments, female mice with one estrogen signal disabled in selected brain cells had greater bone mass at 16 weeks than littermate controls.In experiments, female mice with one estrogen signal disabled in selected brain cells had greater bone mass at 16 weeks than littermate controls.
Mouse studyBones and joints
Who was studiedGonadal-intact female mice, against littermate control mice
What changedFemale mice lacking membrane estrogen signaling in POMC neurons had higher femur bone mass than controls
The catchHigher circulating estrogen could explain cortical bone gains in intact mutant females