Revista Multidisciplinar Do Nordeste Mineiro · Jan 10, 2026
Hormonal interaction and facial aging: a literature review
By Pollon TC, Ribeiro G, Molonha L
Investigation of the hormonal mechanisms involved in changes related to facial aging reveals the importance of these factors in the integrity of facial tissues. This study aimed to review the scientific literature to assess the role of endocrine hormones in morphological changes resulting from aging, highlighting how these biological mediators influence the visible characteristics of the face over time. Research shows that hormonal balance is fundamental to maintaining the structure and function of the skin, muscles, bones, and facial adipose tissue. The decline in sex hormones, such as estrogen in women and testosterone in men, is associated with loss of skin elasticity, bone fragility, and reduced muscle mass. On the other hand, increased cortisol accelerates physical and cognitive degenerative processes, while the decline in growth hormones, such as GH and IGF-1, intensifies muscle atrophy and favors an increase in adipose tissue. Unraveling these mechanisms helps guide interventions capable of promoting healthier aging and preserving the quality of life of older individuals.