Energy metabolism-engaged nanomedicines
1 paper4 findings
- 1 lab in 1 country
- Funder: National Natural Science Foundation of China
- Animals1
Outcomes
4BMMSC stemness and osteogenic potential
upin mice1
1 study
BMMSC stemness and osteogenic potential
upin mice1
Energy metabolism-engaged nanomedicines improve BMMSC stemness and osteogenic potential in mice.
“while simultaneously restoring the stemness and osteogenic potential of aged BMMSCs in situ.”
Animalsin situbone marrow mesenchymal stromal/stem cell
Nature nanotechnology19 Aug 2025
Osteoporotic bone loss
downin mice1
1 study
Osteoporotic bone loss
downin mice1
Energy metabolism-engaged nanomedicines decrease osteoporotic bone loss in mice.
“EM-eNMs selectively target bone tissues through systemic delivery and significantly reverse osteoporotic bone loss in aged mice”
Animalsosteoporotic bone lossbone
Nature nanotechnology19 Aug 2025
Mitochondrial fission and fusion
upin mouse cells1
1 study
Mitochondrial fission and fusion
upin mouse cells1
Energy metabolism-engaged nanomedicines increase mitochondrial fission and fusion in mouse cells.
“EM-eNMs infiltrate the mitochondria of aged bone marrow mesenchymal stromal/stem cells (BMMSCs), driving mitochondrial fission, mitophagy, glycolysis and maintaining BMMSC stemness and multifunction.”
Cellsbone marrow mesenchymal stromal/stem cell
Nature nanotechnology19 Aug 2025
Mitophagy
upin mouse cells1
1 study
Mitophagy
upin mouse cells1
Energy metabolism-engaged nanomedicines increase mitophagy in mouse cells.
“The EM-eNMs directly bind to the ATP synthase and promote mitophagy through induction of the dynamin-related protein 1 (DRP1) gene.”
Cellsbone marrow mesenchymal stromal/stem cell
Nature nanotechnology19 Aug 2025