Emtricitabine + tenofovir disoproxil fumarate

1. Emtricitabine + tenofovir disoproxil fumarate has no effect on biological age in humans.

   “In contrast, the FTC/TDF study (N=43) showed no significant changes across epigenetic clocks and proxies.”

   Human trialhealthy people without HIV200 mg/300 mg12 weeksn = 43

   An FDA-Approved Tenofovir Alafenamide-Based Antiretroviral Therapy Reduces Biological Age in Healthy Adults: First Human Proof-of-Concept for Retrotransposon-Targeted Gerotherapeutics

   medRxiv : the preprint server for health sciences·26 Mar 2026Preprint

1. Emtricitabine + tenofovir disoproxil fumarate induces cellular senescence in human cells.

   “cART treatment induced cellular senescence”

   Cellsin primary human muscle cellsskeletal muscle

   Antiretroviral Therapy Alters Skeletal Muscle DNA Methylation in HIV Mice and Promotes Cellular Senescence

   GSA 2025 abstract·31 Dec 2025

More on Cellular senescence