Diosgenin

1. Diosgenin activates sirtuin signalling in mice.

   “These effects were mediated by direct activation of SIRT1, leading to deacetylation of PGC-1α.”

   Animalsin aged mice and D-galactose-induced senescent C2C12 cells

   Diosgenin Alleviates Age-Related Sarcopenia by Promoting Satellite Cell Proliferation and Myogenic Differentiation via Activation of the SIRT1/PGC-1α Signaling Pathway

   Aging cell·31 Jul 2026

More on Sirtuin signalling

1. Diosgenin increases satellite cell proliferation in mice.

   “increased the number of proliferative satellite cells positive for paired box 7 (Pax7) and Ki67”

   Animals

   Diosgenin Alleviates Age-Related Sarcopenia by Promoting Satellite Cell Proliferation and Myogenic Differentiation via Activation of the SIRT1/PGC-1α Signaling Pathway

   Aging cell·31 Jul 2026

1. Diosgenin increases muscle fiber cross-sectional area in mice.

   “increased the gastrocnemius muscle index, and enlarged muscle fiber cross-sectional area in aged mice”

   Animalsskeletal muscle

   Diosgenin Alleviates Age-Related Sarcopenia by Promoting Satellite Cell Proliferation and Myogenic Differentiation via Activation of the SIRT1/PGC-1α Signaling Pathway

   Aging cell·31 Jul 2026

1. Diosgenin improves forelimb grip strength in mice.

   “Diosgenin treatment significantly improved forelimb grip strength and exercise endurance”

   Animalsskeletal muscle

   Diosgenin Alleviates Age-Related Sarcopenia by Promoting Satellite Cell Proliferation and Myogenic Differentiation via Activation of the SIRT1/PGC-1α Signaling Pathway

   Aging cell·31 Jul 2026

1. Diosgenin lowers the risk of sarcopenia in mice.

   “findings demonstrate that diosgenin alleviates age-related sarcopenia by activating the SIRT1/PGC-1α signaling pathway”

   Animalsin aged mice

   Diosgenin Alleviates Age-Related Sarcopenia by Promoting Satellite Cell Proliferation and Myogenic Differentiation via Activation of the SIRT1/PGC-1α Signaling Pathway

   Aging cell·31 Jul 2026

More on Sarcopenia