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Dietary restriction + fenofibrate + liraglutide + metformin + ramipril + rosuvastatin

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Wellcome Trust
  • Animals1

Outcomes

3

Fatty acid β-oxidation

upin rats1

1 study

  1. Dietary restriction + fenofibrate + liraglutide + metformin + ramipril + rosuvastatin increases fatty acid β-oxidation in rats.

    “dominated by changes in fenofibrate- and peroxisome proliferator-activated receptor-α (PPARα)-governed peroxisomal and mitochondrial FAO transcripts”

    Animalskidneymales

    Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats

    Clinical science (London, England : 1979)Oct 20, 2022

More on Fatty acid β-oxidation

Kidney injury

downin rats1

1 study

  1. Dietary restriction + fenofibrate + liraglutide + metformin + ramipril + rosuvastatin decreases kidney injury in rats.

    “was associated with reductions in indices of glomerular and proximal tubular injury”

    Animalskidneymales

    Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats

    Clinical science (London, England : 1979)Oct 20, 2022

Body weight

downin rats1

1 study

  1. Dietary restriction + fenofibrate + liraglutide + metformin + ramipril + rosuvastatin decreases body weight in rats (∼20%).

    “The DMT protocol led to ∼20% weight loss”

    Animalsmales

    Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats

    Clinical science (London, England : 1979)Oct 20, 2022

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