Dietary advanced glycation end products
- 1 lab in 1 country
- Funders: National Institute on Aging and 2 more
- Animals1
Outcomes
4Inflammation
upin reviews1
1 study
Inflammation
upin reviews1
Dietary advanced glycation end products induce inflammation.
“systemic induction of oxidative stress and chronic inflammation ("inflammaging") through binding and activation of the Receptor for AGEs (RAGE).”
Review
Nutrition, metabolism, and cardiovascular diseases : NMCD30 Dec 2025
Oxidative stress and ROS signalling
upin reviews1
1 study
Oxidative stress and ROS signalling
upin reviews1
Dietary advanced glycation end products induce oxidative stress and ROS signalling.
“systemic induction of oxidative stress and chronic inflammation ("inflammaging") through binding and activation of the Receptor for AGEs (RAGE).”
Review
Nutrition, metabolism, and cardiovascular diseases : NMCD30 Dec 2025
Cellular senescence
upin reviews1
1 study
Cellular senescence
upin reviews1
Dietary advanced glycation end products induce cellular senescence.
“dietary and endogenous AGEs contribute to cellular senescence and the progression of prevalent age-associated pathologies”
Review
Biochimie3 Jun 2025
Lifespan
downin mice1
1 study
Lifespan
downin mice1
Dietary advanced glycation end products shorten lifespan in mice.
“there was an inverse correlation between the dietary AGE content, the AGER1 to receptor for AGE (RAGE) ratio, OS, organ damage, and life span”
Animalsinverse correlation
Advanced glycation end product homeostasis: exogenous oxidants and innate defenses
Annals of the New York Academy of Sciences1 Apr 2008
Associations
2Insulin resistance
upin reviews1
1 study
Insulin resistance
upin reviews1
Dietary advanced glycation end products raise the risk of insulin resistance.
“This persistent systemic load-heavily contributed by high-fat, high-protein foods cooked at dry, high heat-is implicated in accelerating insulin resistance, cardiovascular complications, and neurodegeneration.”
Review
Nutrition, metabolism, and cardiovascular diseases : NMCD30 Dec 2025
Chronic disease
upin reviews1
1 study
Chronic disease
upin reviews1
Dietary advanced glycation end products are associated with chronic disease.
“The accumulation of AGEs in body tissues has been associated with aging and the pathogenesis of various non-communicable diseases.”
Review
Biochimie3 Jun 2025
Funding
2 grants since 2023National Institute on AgingUS$1.6mRutgers, The State University of New JerseyUS$9.8k