Dichloroacetic acid

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Japan Science and Technology Agency and 2 more

Animals1

Outcomes

Electron transport chain gene expression

upin mice1

1 study

Dichloroacetic acid increases electron transport chain gene expression in mice.
“increased the expression of genes that encode the electron transportation chain components”
Animalschronic calcineurin inhibitor nephrotoxicity mouse modelkidney
Pyruvate Dehydrogenase and Cellular Metabolism in Calcineurin Inhibitor-Induced Kidney Fibrosis
Journal of the American Society of Nephrology : JASN29 Aug 2025

More on Electron transport chain gene expression

Kidney fibrosis

downin mice1

1 study

Dichloroacetic acid decreases kidney fibrosis in mice.
“administration of dichloroacetic acid, a known activator of pyruvate dehydrogenase, in the chronic CNI nephrotoxicity mouse model mitigated kidney fibrosis”
Animalschronic calcineurin inhibitor nephrotoxicity mouse modelkidney
Pyruvate Dehydrogenase and Cellular Metabolism in Calcineurin Inhibitor-Induced Kidney Fibrosis
Journal of the American Society of Nephrology : JASN29 Aug 2025