Decellularized aged bruch's membrane
1 paper studies it3 findings
Across all fields, 1 paper: 1 observational study in people
- 1 lab in 1 country
- Funders: Instituto de Salud Carlos III and 1 more
- Humans1
Outcomes
3Lipid and ceramide metabolism
upin human cells1
1 study
Lipid and ceramide metabolism
upin human cells1
Decellularized aged bruch's membrane increases lipid and ceramide metabolism in human cells.
“marked expression of drusen components such as vitronectin and apolipoprotein E, lipid deposition and complement factors C3 and C9.”
Cellsin RPE monolayersretinal pigment epithelium
Aging cell
IL-33
upin human cells1
1 study
IL-33
upin human cells1
Decellularized aged bruch's membrane increases IL-33 in human cells.
“accompanied by increased IL-33 secretion and marked expression of drusen components such as vitronectin and apolipoprotein E”
Cellsafter 60 days of culture compared to young dECM-BrMretinal pigment epithelium60 days
Aging cell
Transepithelial electrical resistance
downin human cells1
1 study
Transepithelial electrical resistance
downin human cells1
Decellularized aged bruch's membrane decreases transepithelial electrical resistance in human cells.
“after 60 days, transepithelial electrical resistance significantly decreased compared to RPE grown on young dECM-BrM”
Cellsafter 60 days of culture compared to young dECM-BrMretinal pigment epithelium60 days
Aging cell