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Death receptor 5 agonistic antibody

Intervention

2 papers study it2 findings

Across all fields, 2 papers: none in people yet, 2 in animals

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 2 countries
  • Animals2

Outcomes

1

Cell killing (cytotoxicity)

upin cells1

1 study

  1. Death receptor 5 agonistic antibody increases cell killing (cytotoxicity) in cells.

    “senescent cells sensitize adjacent non-senescent cells to killing by DR5 agonist through a bystander effect mediated by secretion of cytokines.”

    Cellsadjacent to senescent cells

    cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis

    Nature cancer

  2. Death receptor 5 agonistic antibody induces cell killing (cytotoxicity) in cells.

    “Activation of DR5 signaling by agonistic antibody, which can be enhanced further by suppression of cFLIP by BRD2 inhibition, leads to efficient killing of a variety of senescent cancer cells.”

    Cellssenescent cancer cells

    cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis

    Nature cancer

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