Daucosterol

1. Daucosterol activates NRF2–KEAP1 antioxidant response in mouse cells.

   “Furthermore, DAU restored mitochondrial membrane potential, reduced reactive oxygen species (ROS) production, and activated the NRF2 antioxidant pathway.”

   Cellsin chondrocytes

   Daucosterol alleviates osteoarthritis by targeting chondrocyte senescence via inhibiting of the JNK pathway

   International immunopharmacology·2 Mar 2026

More on NRF2–KEAP1 antioxidant response

1. Daucosterol inhibits JNK signalling in mouse cells.

   “Mechanistically, DAU selectively inhibited the c-Jun N-terminal kinase (JNK) pathway.”

   Cellsin chondrocytes

   Daucosterol alleviates osteoarthritis by targeting chondrocyte senescence via inhibiting of the JNK pathway

   International immunopharmacology·2 Mar 2026

More on JNK signalling

1. Daucosterol inhibits cellular senescence in mouse cells.

   “DAU inhibited IL-1β-induced senescence, inflammation, and matrix degradation in chondrocytes, and simultaneously enhanced extracellular matrix (ECM) production.”

   Cellsin IL-1β-stimulated murine chondrocytes

   Daucosterol alleviates osteoarthritis by targeting chondrocyte senescence via inhibiting of the JNK pathway

   International immunopharmacology·2 Mar 2026

More on Cellular senescence

1. Daucosterol decreases cartilage degradation in mice.

   “In the mouse DMM models, intra-articular DAU administration alleviated cartilage degradation and reduced senescence marker P16 expression.”

   Animalsin mouse DMM modelsintra-articular DAU administration

   Daucosterol alleviates osteoarthritis by targeting chondrocyte senescence via inhibiting of the JNK pathway

   International immunopharmacology·2 Mar 2026