Papers on dasatinib + quercetin

391 papers7 new in 30 days

Thursday, September 5

International Journal of SurgerySep 5

Human umbilical cord mesenchymal stem cells-derived extracellular vesicles ameliorate kidney ischemia-reperfusion injury by suppression of senescent tubular epithelial cells: experimental study

Experiments in miceKidney

Paper

Wednesday, August 21

Investigative Ophthalmology & Visual ScienceAug 21

Cholesterol Accumulation Promotes Photoreceptor Senescence and Retinal Degeneration

Experiments in miceAge-related macular degeneration

Paper

Friday, August 9

GeroScienceAug 9

Senolytic intervention improves cognition, metabolism, and adiposity in female APPNL-F/NL-F mice

Experiments in miceSenolytics

Paper

CellsAug 9

Senolytics and Senomorphics Targeting p38MAPK/NF-κB Pathway Protect Endothelial Cells from Oxidative Stress-Mediated Premature Senescence

Experiments in human cellsSenolytics

Paper

bioRxivAug 9

Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APP NL-F/NL-F Mice

Preprint: experiments in miceSenolytics

Paper

Tuesday, August 6

Scientific ReportsAug 6

A comprehensive single-cell RNA transcriptomic analysis identifies a unique SPP1+ macrophages subgroup in aging skeletal muscle

Experiments in miceMuscle

Paper

Sunday, July 28

Scientific ReportsJul 28

MASLD does not affect fertility and senolytics fail to prevent MASLD progression in male mice

Experiments in miceSenolytics

Paper

Saturday, July 20

Aging CellJul 20

Prophylactic senolytic treatment in aged mice reduces seizure severity and improves survival from Status Epilepticus

Experiments in miceSenolytics

Paper

Thursday, July 18

Cell ProliferationJul 18

Cellular senescence mediates retinal ganglion cell survival regulation post-optic nerve crush injury

Experiments in miceEye

Paper

Wednesday, July 3

Nature MedicineJul 3

Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial

Randomized trial in 60 peopleSenolytics

Paper

Thursday, May 30

Frontiers in Aging NeuroscienceMay 30

Failure of senolytic treatment to prevent cognitive decline in a female rodent model of aging

Experiments in ratsSenolytics

Paper

Sunday, May 26

Advanced Healthcare MaterialsMay 26

Senolytic Therapy Enabled by Senescent Cell-Sensitive Biomimetic Melanin Nano-Senolytics

Experiments in miceSenolytics

Paper

Saturday, May 25

Advanced Healthcare MaterialsMay 25

Targeted Clearance of Senescent Cells Via Engineered Extracellular Vesicles Reprograms Tumor Immunosuppressive Microenvironment

Experiments in miceInterventions

Paper

Tuesday, May 21

Aging CellMay 21

Accumulation of senescent cells in the adrenal gland induces hypersecretion of corticosterone via IL1β secretion

Experiments in miceInterventions

Paper

Monday, May 20

Clinical and Translational MedicineMay 20

Downregulated SPESP1-driven fibroblast senescence decreases wound healing in aged mice

Experiments in miceSkin

Paper

Sunday, May 19

PhytomedicineMay 19

Senolytic combination of dasatinib and quercetin attenuates renal damage in diabetic kidney disease

Experiments in miceSenolytics

Paper

Tuesday, May 7

Nature NeuroscienceMay 7

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy

Study in peopleSenolytics

Paper

Thursday, May 2

European Journal of PharmacologyMay 2

Combination of Dasatinib and Quercetin alleviates heat stress-induced cognitive deficits in aged and young adult male mice

Experiments in miceDasatinib + quercetin

Paper

Saturday, April 27

Biomedicine & PharmacotherapyApr 27

Senolytics ameliorate the failure of bone regeneration through the cell senescence-related inflammatory signalling pathway

Experiments in ratsSenolytics

Paper

Monday, April 15

BiogerontologyApr 15

Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo

Experiments in miceDasatinib + quercetin

Paper

Sunday, April 14

ToxicologyApr 14

The p21⁺ perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying regeneration

Study in peopleCDKN1A

Paper

Saturday, April 13

International Journal of Molecular SciencesApr 13

The Differential Effect of Senolytics on SASP Cytokine Secretion and Regulation of EMT by CAFs

Experiments in mouse cellsSenolytics

Paper

Thursday, April 11

Molecular Human ReproductionApr 11

Cellular senescence of granulosa cells in the pathogenesis of polycystic ovary syndrome

Study in peoplePolycystic ovary syndrome

Paper

Saturday, March 23

Biomedicine & PharmacotherapyMar 23

Senolytic drugs dasatinib and quercetin combined with Carboplatin or Olaparib reduced the peritoneal and adipose tissue metastasis of ovarian cancer

Experiments in miceDasatinib

Paper

Monday, March 18

Research SquareMar 18

Evaluation of Exploratory Fluid Biomarker Results from a Phase 1 Senolytic Trial in Mild Alzheimer's Disease

Preprint: non-randomized trial in peopleSenolytics

Paper

Friday, March 15

Neuroscience LettersMar 15

Senolytics prevent age-associated changes in female mice brain

Experiments in miceSenolytics

Paper

Sunday, March 10

Journal of Alzheimer's DiseaseMar 10

A Need for Refined Senescence Biomarkers and Measures of Senolytics in the Brain

CommentaryBiomarkers

Paper

Thursday, February 22

AgingFeb 22

Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions

Non-randomized trial in 19 peopleSenolytics

Paper

Thursday, February 15

GeroScienceFeb 15

Senolytic treatment fails to improve ovarian reserve or fertility in female mice

Experiments in 30 miceSenolytics

Paper

Friday, February 2

Journal of Alzheimer's DiseaseFeb 2

Senescence Targeting Methods Impact Alzheimer's Disease Features in 3xTg Mice

Experiments in miceAlzheimer's disease

Paper