Papers on dasatinib + quercetin

392 papers8 new in 30 days

Friday, January 19

International Journal of Molecular MedicineJan 19

Senolytic combination of dasatinib and quercetin protects against diabetic kidney disease by activating autophagy to alleviate podocyte dedifferentiation via the Notch pathway

Experiments in miceSenolytics

Paper

Thursday, January 18

GeroScienceJan 18

Senolytic treatment does not mitigate oxidative stress-induced muscle atrophy but improves muscle force generation in CuZn superoxide dismutase knockout mice

Experiments in miceSenolytics

Paper

Saturday, January 13

GeroScienceJan 13

Eliminating senescent cells by white adipose tissue-targeted senotherapy alleviates age-related hepatic steatosis through decreasing lipolysis

Experiments in animalsHepatic steatosis

Paper

Friday, January 5

Cardiovascular ResearchJan 5

The role of cellular senescence in profibrillatory atrial remodelling associated with cardiac pathology

Experiments in ratsInterventions

Paper

Saturday, December 23

International Journal of Molecular SciencesDec 23

The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency

Experiments in miceReproductive system

Paper

Thursday, December 21

ArthroscopyDec 21

Editorial Commentary: Dasatinib With Quercetin Shows Promise in Decreasing Age-Related Senescence in the Rotator Cuff Tendon-Can It Work Elsewhere?

Experiments in human cellsDasatinib

Paper

Wednesday, December 13

ACS Materials AuDec 13

Antisenescence Therapy Improves Function in a Human Model of Cardiac Fibrosis-on-a-Chip

Experiments in human cellsCardiac fibrosis

Paper

Saturday, November 25

International Journal of Molecular SciencesNov 25

Cellular Senescence: A Troy Horse in Pulmonary Fibrosis

ReviewCellular senescence

Paper

Tuesday, October 24

The Journal of Prevention of Alzheimer's DiseaseOct 24

Translating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics

ReviewSenolytics

Paper

Sunday, October 15

Aging CellOct 15

Senolytics prevent caveolar CaV 3.2-RyR axis malfunction in old vascular smooth muscle

Experiments in miceSenolytics

Paper

Tuesday, October 10

Aging and DiseaseOct 10

Senolytic Treatment Improve Small Intestine Regeneration in Aging

Experiments in miceSenolytics

Paper

Wednesday, October 4

bioRxivOct 4

NEUROMETABOLOMIC IMPACTS OF MODELED WILDFIRE SMOKE AND PROTECTIVE BENEFITS OF ANTI-AGING THERAPEUTICS IN AGED FEMALE C57BL/6J MICE

Preprint: experiments in 6 miceInterventions

Paper

Tuesday, September 26

Investigative Ophthalmology & Visual ScienceSep 26

Dasatinib Plus Quercetin Alleviates Choroid Neovascularization by Reducing the Cellular Senescence Burden in the RPE-Choroid

Experiments in ratsDasatinib + quercetin

Paper

Tuesday, September 12

Nephrology, Dialysis, TransplantationSep 12

Single-cell RNA sequencing identifies senescence as therapeutic target in rhabdomyolysis-induced acute kidney injury

Experiments in miceAcute kidney injury

Paper

Friday, September 8

Nature MedicineSep 8

Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial

Non-randomized trial in 5 peopleAlzheimer's disease

Paper

Thursday, September 7

Research SquareSep 7

Senolytic therapy to modulate the progression of Alzheimer's Disease (SToMP-AD) - Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease

Preprint: non-randomized trial in 5 peopleAlzheimer's disease

Paper

Thursday, August 24

MedCommAug 24

Cellular senescence primes liver fibrosis regression through Notch-EZH2

Experiments in miceLiver fibrosis

Paper

Wednesday, August 16

Cellular & Molecular Biology LettersAug 16

Astrocyte senescence-like response related to peripheral nerve injury-induced neuropathic pain

Experiments in ratsInterventions

Paper

Monday, August 14

Frontiers in NeuroscienceAug 14

Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice

Experiments in miceSenolytics

Paper

Monday, July 3

Frontiers in AgingJul 3

Senolytic treatment with dasatinib and quercetin does not improve overall influenza responses in aged mice

Experiments in miceSenolytics

Paper

Thursday, June 29

Aging BiologyJun 29

Senolytics Reduce Endothelial Cell DNA Damage and Telomere Dysfunction Despite Reductions in Telomere Length

Experiments in miceSenolytics

Paper

Friday, June 23

ArthroscopyJun 23

Human Rotator Cuff Tears Reveal an Age-Dependent Increase in Markers of Cellular Senescence and Selective Removal of Senescent Cells With Dasatinib + Quercetin Increases Genetic Expression of COL1A1 In Vitro

Experiments in human cellsDasatinib + quercetin

Paper

Saturday, June 17

NPJ Regenerative MedicineJun 17

A short dasatinib and quercetin treatment is sufficient to reinstate potent adult neuroregenesis in the aged killifish

Experiments in killifishDasatinib + quercetin

Paper

Saturday, June 10

GeroScienceJun 10

Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral treatment

Experiments in miceDasatinib

Paper

Thursday, June 1

GeroScienceJun 1

Long-term dasatinib plus quercetin effects on aging outcomes and inflammation in nonhuman primates: implications for senolytic clinical trial design

Experiments in animalsDasatinib

Paper

Wednesday, May 31

International Journal of Oral ScienceMay 31

RANKL⁺ senescent cells under mechanical stress: a therapeutic target for orthodontic root resorption using senolytics

Experiments in ratsSenolytics

Paper

Saturday, May 27

BiologyMay 27

Therapeutic Potential of a Senolytic Approach in a Murine Model of Chronic GVHD

Experiments in miceSenolytics

Paper

Friday, May 26

Physiology InternationalMay 26

Dasatinib and quercetin increase testosterone and sperm concentration in mice

Experiments in 9 miceDasatinib

Paper

Friday, May 19

AgingMay 19

Senescence and senotherapies in biliary atresia and biliary cirrhosis

Experiments in ratsInterventions

Paper

Friday, April 28

International Journal of Molecular SciencesApr 28

Impact of Senolytic Treatment on Gene Expression in Aged Lung

Experiments in miceSenolytics

Paper