Cyclodextrin

  • 1 lab in 1 country
  • Funders: National Institute of Neurological Disorders and Stroke and 1 more
  • Animals1

Outcomes

1

Cellular senescence

downin mice1

1 study
  1. Cyclodextrin decreases cellular senescence in mice.

    “Treatment of APOE4-TR mice with cyclodextrin reduced brain oxysterol levels, ABCA1 lysosome trapping, mTORC1 activation, and attenuated senescence and neuroinflammation markers.”

    Animalsin APOE4-TR micebrain

    Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD

    Molecular neurodegeneration4 Feb 2025

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