AgingResearch.NewsJoin free

Metformin + curcumin

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Animals1

Outcomes

2

Locomotor activity

upin rats1

1 study

  1. Metformin + curcumin improves locomotor activity in rats.

    “The optimized nano-formulations also exhibited anti-edematous, anti-nociceptive, and locomotor-enhancing activity”

    AnimalsMIA-induced OAnano-formulations

    Intra-articular metformin-curcumin cationic PLGA nanoparticles rejuvenate articular structure in MIA induced osteoarthritis model via modulating the crosstalk between miR93, TNFAIP3/TLR/NF-κB and AMPK/SIRT1 trajectories

    International journal of biological macromolecules22 May 2025

Osteoarthritis

downin rats1

1 study

  1. Metformin + curcumin protects against osteoarthritis in rats.

    “Treatment with HA-MT-Cu-cPL4 showed the most significant repression of OA advancement”

    AnimalsMIA-induced OAhyaluronic acid-coated cationic PLGA nanoparticles loaded with metformin and curcumin (HA-MT-Cu-cPL4)knee joint

    Intra-articular metformin-curcumin cationic PLGA nanoparticles rejuvenate articular structure in MIA induced osteoarthritis model via modulating the crosstalk between miR93, TNFAIP3/TLR/NF-κB and AMPK/SIRT1 trajectories

    International journal of biological macromolecules22 May 2025

More on Osteoarthritis

Latest

Related