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Copper-dihydromyricetin nanoparticle-loaded hydrogel-coated titanium implant

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Fundamental Research Funds for the Central Universities and 1 more
  • Animals1

Outcomes

5

Angiogenesis

upin animals1

1 study

  1. Copper-dihydromyricetin nanoparticle-loaded hydrogel-coated titanium implant increases angiogenesis in animals.

    “In vivo animal experiments demonstrate that the material accelerates bone repair by restoring local microenvironmental homeostasis and promoting vascularization.”

    Animalsbone

    Breaking Age-Impaired Bone Healing Challenge: Smart Hydrogel-Coated Implant Reprograms Aging Bone Microenvironments via Senolytic and Pro-Angiogenic Dual Therapy

    Advanced healthcare materials14 Sep 2025

More on Angiogenesis

Bone repair

upin animals1

1 study

  1. Copper-dihydromyricetin nanoparticle-loaded hydrogel-coated titanium implant improves bone repair in animals.

    “In vivo animal experiments demonstrate that the material accelerates bone repair by restoring local microenvironmental homeostasis and promoting vascularization.”

    Animalsbone

    Breaking Age-Impaired Bone Healing Challenge: Smart Hydrogel-Coated Implant Reprograms Aging Bone Microenvironments via Senolytic and Pro-Angiogenic Dual Therapy

    Advanced healthcare materials14 Sep 2025

Cellular senescence

downin animals cells1

1 study

  1. Copper-dihydromyricetin nanoparticle-loaded hydrogel-coated titanium implant decreases cellular senescence in animals cells.

    “directly decelerates the senescence of mesenchymal stem cells (MSCs)”

    Cellsmesenchymal stem cell

    Breaking Age-Impaired Bone Healing Challenge: Smart Hydrogel-Coated Implant Reprograms Aging Bone Microenvironments via Senolytic and Pro-Angiogenic Dual Therapy

    Advanced healthcare materials14 Sep 2025

More on Cellular senescence

Mitochondrial metabolic function

upin animals cells1

1 study

  1. Copper-dihydromyricetin nanoparticle-loaded hydrogel-coated titanium implant improves mitochondrial metabolic function in animals cells.

    “restores mitochondrial metabolic function”

    Cells

    Breaking Age-Impaired Bone Healing Challenge: Smart Hydrogel-Coated Implant Reprograms Aging Bone Microenvironments via Senolytic and Pro-Angiogenic Dual Therapy

    Advanced healthcare materials14 Sep 2025

Reactive oxygen species

downin animals cells1

1 study

  1. Copper-dihydromyricetin nanoparticle-loaded hydrogel-coated titanium implant decreases reactive oxygen species in animals cells.

    “This mechanism effectively scavenges excessive intracellular and extracellular ROS accumulation”

    Cellsoxidative stress conditions linked to cellular senescence

    Breaking Age-Impaired Bone Healing Challenge: Smart Hydrogel-Coated Implant Reprograms Aging Bone Microenvironments via Senolytic and Pro-Angiogenic Dual Therapy

    Advanced healthcare materials14 Sep 2025

More on Reactive oxygen species

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