Contextual fear conditioning
2 papers3 findings
- 2 independent labs in 2 countries
- Funders: National Institute of Mental Health and 6 more
- Animals1
- In silico1
Outcomes
3Multi-spine bouton complexity
downin mice1
1 study
Multi-spine bouton complexity
downin mice1
Contextual fear conditioning decreases multi-spine bouton complexity in mice.
“unexpectedly, MSB complexity, decreases in CA1 stratum radiatum 24 h after CFC.”
Animalshippocampal CA1 stratum radiatum24 h
Molecular brain2 Dec 2025
K48 polyubiquitination
upin rats1
1 study
K48 polyubiquitination
upin rats1
Contextual fear conditioning increases K48 polyubiquitination in rats.
“contextual fear conditioning led to an increase in proteasome activity and K48 polyubiquitin protein targeting in the hippocampus of aged male rats”
Animalsagedhippocampusmales
Dysregulation of baseline and learning-dependent protein degradation in the aged hippocampus
Brain research bulletin13 Jun 2024
Proteasome concentration
upin rats1
1 study
Proteasome concentration
upin rats1
Contextual fear conditioning increases proteasome concentration in rats.
“contextual fear conditioning led to an increase in proteasome activity and K48 polyubiquitin protein targeting in the hippocampus of aged male rats”
Animalsagedhippocampusmales
Dysregulation of baseline and learning-dependent protein degradation in the aged hippocampus
Brain research bulletin13 Jun 2024
Latest
1 in 12 monthsMolecular Brain
Aging-independent decrease of complex multi-spine boutons in hippocampal area CA1 after contextual fear conditioning
Computational studyMechanisms
Brain Research Bulletin
Dysregulation of baseline and learning-dependent protein degradation in the aged hippocampus
Experiments in ratsMechanisms