Cognitive behavioural therapy for insomnia

3 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Institute on Aging and 1 more

Human trial2

Outcomes

5

Insomnia disorder

downin humans1

1 study

Cognitive behavioural therapy for insomnia decreases insomnia disorder in humans (34% [16 of 47] vs 13% [six of 45]).
“Participants receiving CBT-I in the current analysis were more likely to have full remission following treatment than those receiving SET (34% [16 of 47] vs 13% [six of 45]).”
Human trialolder adults with insomnia
Cognitive behavioural therapy for insomnia and epigenetic ageing: secondary analysis from a randomised controlled trial
The lancet. Healthy longevity12 Aug 2026

More on Insomnia disorder

PhenoAge

no changein humans1

1 study

Cognitive behavioural therapy for insomnia has no effect on PhenoAge in humans (-0.49, -1.34 to 0.36).
“No statistically significant differences were observed for GrimAge (-0·33, -0·68 to 0·03, FDR-adjusted p=0·11) and PCPhenoAge (-0·49, -1·34 to 0·36, FDR-adjusted p=0·26).”
Human trialolder adults with insomniaPBMC
Cognitive behavioural therapy for insomnia and epigenetic ageing: secondary analysis from a randomised controlled trial
The lancet. Healthy longevity12 Aug 2026

More on PhenoAge

GrimAge

no changein humans1

1 study

Cognitive behavioural therapy for insomnia has no effect on GrimAge in humans (-0.33, -0.68 to 0.03).
“No statistically significant differences were observed for GrimAge (-0·33, -0·68 to 0·03, FDR-adjusted p=0·11) and PCPhenoAge (-0·49, -1·34 to 0·36, FDR-adjusted p=0·26).”
Human trialolder adults with insomniaPBMC
Cognitive behavioural therapy for insomnia and epigenetic ageing: secondary analysis from a randomised controlled trial
The lancet. Healthy longevity12 Aug 2026

More on GrimAge

DunedinPACE

downin humans1

1 study

Cognitive behavioural therapy for insomnia decreases DunedinPACE in humans (-0.02, 95% CI -0.04 to -0.01).
“Compared with those receiving SET, older adults receiving CBT-I showed a significantly slower pace of biological ageing, as estimated by DunedinPACE (-0·02, 95% CI -0·04 to -0·01, false discovery rate [FDR]-adjusted p=0·03).”
Human trialolder adults with insomniaPBMC
Cognitive behavioural therapy for insomnia and epigenetic ageing: secondary analysis from a randomised controlled trial
The lancet. Healthy longevity12 Aug 2026

More on DunedinPACE

Insomnia severity

downin humans1

1 study

Cognitive behavioural therapy for insomnia decreases insomnia severity in humans (reduction of 11.19 (95% CI 10.06 to 12.32)).
“while the CBT-I group had a reduction of 11.19 (10.06 to 12.32)”
Human trialchronic insomnia3 monthsn = 100
Tai chi or cognitive behavioural therapy for treating insomnia in middle aged and older adults: randomised non-inferiority trial
BMJ (Clinical research ed.)26 Nov 2025

Latest

3 in 12 months

The Lancet Healthy Longevity12 Aug

Cognitive behavioural therapy for insomnia and epigenetic ageing: secondary analysis from a randomised controlled trial

Randomised trial in peopleInterventions

AAIC 2025 Abstract26 Dec

Double blind clinical trial of lemborexant for AD prevention: Protocol for a randomized controlled clinical trial

Study protocolInterventions

BMJ26 Nov

Tai chi or cognitive behavioural therapy for treating insomnia in middle aged and older adults: randomised non-inferiority trial

Randomised trial in 200 peopleTai chi