Insomnia disorder

Disease1 paper3 findings

Humans1

Effects

3

DTI-ALPS index

downin humans1

1 study

Insomnia disorder decreases DTI-ALPS index in humans.
Humanscompared with healthy controlsbrainn = 80
Working memory deficits under high cognitive load in older adults with insomnia disorder: associations with frontoparietal control network connectivity and glymphatic function · Research Square · 2 Sep 2026 · Preprint

DTI-ALPS index →

Frontoparietal control network functional connectivity

downin humans1

1 study

Insomnia disorder decreases frontoparietal control network functional connectivity in humans.
Humanscompared with healthy controlsbrainn = 80
Working memory deficits under high cognitive load in older adults with insomnia disorder: associations with frontoparietal control network connectivity and glymphatic function · Research Square · 2 Sep 2026 · Preprint

Working memory

downin humans1

1 study

Insomnia disorder impairs working memory in humans.
Humanscompared with healthy controlsn = 80
Working memory deficits under high cognitive load in older adults with insomnia disorder: associations with frontoparietal control network connectivity and glymphatic function · Research Square · 2 Sep 2026 · Preprint

Trial sponsors

Ache Laboratorios Farmaceuticos
Company1 trialPhase 2/3307 people
University of Pennsylvania
1 trialPhase 41,200 people
Idaho State University
1 trial37 people

Latest

3

Preprints.orgReviewPreprint29 Sep

When Insomnia Becomes an Economic Disease: Linking Phenotype, Comorbidity, Treatment, and Societal Cost—An Evidence-Based Narrative Review

Sleep MedicineReview24 Sep

Sleep deprivation as a multi-system physiological stressor: A review of shared mechanisms and clinical implications

Research SquareHumansPreprint3 Sep

Working memory deficits under high cognitive load in older adults with insomnia disorder: associations with frontoparietal control network connectivity and glymphatic function

DTI-ALPS index1