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Cibinetide

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Institutes of Health
  • 4 of 4 findings with company ties
  • Animals1

Outcomes

5

Autophagy

upin rats1

1 study

  1. Cibinetide activates autophagy in rats.

    “ARA290 treatment enhanced cardiomyocyte autophagy flux”

    Animalsheart15 months

    A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan

    Frontiers in cardiovascular medicineJan 18, 2023

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Frailty

downin rats1

1 study

  1. Cibinetide decreases frailty in rats.

    “ARA290 preserved body weight and significantly reduced other markers of organism-wide frailty at the end of life.”

    Animals15 months

    A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan

    Frontiers in cardiovascular medicineJan 18, 2023

Blood pressure

downin rats1

1 study

  1. Cibinetide decreases blood pressure in rats.

    “ARA290 significantly blunted the age-associated elevation in blood pressure”

    Animals15 months

    A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan

    Frontiers in cardiovascular medicineJan 18, 2023

Left ventricular ejection fraction

upin rats1

1 study

  1. Cibinetide improves left ventricular ejection fraction in rats.

    “ARA290 significantly blunted the age-associated elevation in blood pressure and preserved the LV ejection fraction.”

    Animalsheart15 months

    A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan

    Frontiers in cardiovascular medicineJan 18, 2023

Inflammation

downin rats1

1 study

  1. Cibinetide decreases inflammation in rats.

    “ARA290 (cibinetide), an 11-aa non-hematopoietic peptide sequence within the cardioprotective domain of erythropoietin, mediates tissue protection by reducing inflammation and fibrosis.”

    Reviewheart15 months

    A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan

    Frontiers in cardiovascular medicineJan 18, 2023

More on Inflammation

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