Chemical reprogramming cocktail
1 paper4 findings
- 1 lab in 1 country
- Funders: Dana-Farber/Harvard Cancer Center and 4 more
- Animals1
Outcomes
4Mitochondrial fission and fusion
upin mouse cells1
1 study
Mitochondrial fission and fusion
upin mouse cells1
Chemical reprogramming cocktail increases mitochondrial fission and fusion in mouse cells.
“increases the size of mitochondria, alters cristae morphology, causes an increased fusing of mitochondrial networks, and speeds up movement velocity”
Cellsin aged mouse fibroblasts
Aging cell27 Jan 2026
Lipid droplet accumulation
upin mice1
1 study
Lipid droplet accumulation
upin mice1
Chemical reprogramming cocktail increases lipid droplet accumulation in mice.
“In the livers and kidneys of these animals, we observe significant increases in lipid droplet accumulation”
Animalshigher dosesliver, kidney
Aging cell27 Jan 2026
Body weight
downin mice1
1 study
Body weight
downin mice1
Chemical reprogramming cocktail decreases body weight in mice.
“at higher doses, the cocktail causes a drastic reduction in body weight necessitating euthanasia”
Animalshigher doses
Aging cell27 Jan 2026
Transcriptomic age
no changein mice1
1 study
Transcriptomic age
no changein mice1
Chemical reprogramming cocktail has no effect on transcriptomic age in mice.
“no effect on the transcriptomic age of kidney or liver tissues”
Animalslower doseskidney, liver
Aging cell27 Jan 2026