Cerium oxide nanoparticles

Intervention

3 papers9 findings

  • 3 independent labs in 2 countries
  • Funders: Fundamental Research Funds for the Central Universities and 7 more
  • Humans1
  • Animals1
  • Cells1

Outcomes

7

Cellular senescence

downin animalia cells1downin cells1

2 studies
  1. Cerium oxide nanoparticles decrease cellular senescence in animalia cells.

    “WY-PEG-CeO demonstrated significant efficacy in inhibiting oxidative stress, cellular senescence, and extracellular matrix degradation in OA chondrocytes.”

    Cellsosteoarthritis

    Cartilage-targeting peptide-modified cerium oxide nanoparticles alleviate oxidative stress and cartilage damage in osteoarthritis

    Journal of nanobiotechnologyDec 19, 2024

  2. Cerium oxide nanoparticles decrease cellular senescence in cells.

    “thereby reducing the level of senescence”

    Cellsin radiation-induced senescent bone cells

    Protective Role of Nanoceria-Infused Nanofibrous Scaffold toward Bone Tissue Regeneration with Senescent Cells

    BiomacromoleculesJun 5, 2024

More on Cellular senescence

Oxidative stress and ROS signalling

downin animalia cells1downin human cells1

2 studies
  1. Cerium oxide nanoparticles decrease oxidative stress and ROS signalling in animalia cells.

    “WY-PEG-CeO demonstrated significant efficacy in inhibiting oxidative stress, cellular senescence, and extracellular matrix degradation in OA chondrocytes.”

    Cellsosteoarthritis

    Cartilage-targeting peptide-modified cerium oxide nanoparticles alleviate oxidative stress and cartilage damage in osteoarthritis

    Journal of nanobiotechnologyDec 19, 2024

  2. Cerium oxide nanoparticles decrease oxidative stress and ROS signalling in human cells.

    “CeONPs were found to be protective against age-induced oxidative damage in erythrocytes such as reduced levels of antioxidants and increased levels of oxidative species.”

    Cellsage-induced oxidative stresserythrocyte

    Exploring the anti-aging effect of dextran and polyethylene glycol-coated cerium oxide nanoparticles in erythrocytes

    International journal of biological macromoleculesOct 19, 2024

More on Oxidative stress and ROS signalling

Osteoarthritis

downin animalia1

1 study
  1. Cerium oxide nanoparticles decrease osteoarthritis in animalia.

    “Animal models further revealed that WY-PEG-CeO exhibited a prolonged residence time and enhanced penetration efficiency in cartilage tissue, leading to the attenuation of pathological changes in OA.”

    Animalsosteoarthritis

    Cartilage-targeting peptide-modified cerium oxide nanoparticles alleviate oxidative stress and cartilage damage in osteoarthritis

    Journal of nanobiotechnologyDec 19, 2024

More on Osteoarthritis

Extracellular matrix remodelling

downin animalia cells1

1 study
  1. Cerium oxide nanoparticles decrease extracellular matrix remodelling in animalia cells.

    “WY-PEG-CeO demonstrated significant efficacy in inhibiting oxidative stress, cellular senescence, and extracellular matrix degradation in OA chondrocytes.”

    Cellsosteoarthritis

    Cartilage-targeting peptide-modified cerium oxide nanoparticles alleviate oxidative stress and cartilage damage in osteoarthritis

    Journal of nanobiotechnologyDec 19, 2024

More on Extracellular matrix remodelling

Membrane integrity

upin human cells1

1 study
  1. Cerium oxide nanoparticles improve membrane integrity in human cells.

    “Pretreatment with NPs protected the morphology and membrane integrity of erythrocytes.”

    Cellserythrocyte

    Exploring the anti-aging effect of dextran and polyethylene glycol-coated cerium oxide nanoparticles in erythrocytes

    International journal of biological macromoleculesOct 19, 2024

More on Membrane integrity

Osteogenesis

upin cells1

1 study
  1. Cerium oxide nanoparticles increase osteogenesis in cells.

    “and promoting osteogenesis”

    Cellsin radiation-induced senescent bone progenitor cells

    Protective Role of Nanoceria-Infused Nanofibrous Scaffold toward Bone Tissue Regeneration with Senescent Cells

    BiomacromoleculesJun 5, 2024

Reactive oxygen species

downin cells1

1 study
  1. Cerium oxide nanoparticles decrease reactive oxygen species in cells.

    “presence of ceria can modulate ROS levels”

    Cellsin radiation-induced senescent bone cells

    Protective Role of Nanoceria-Infused Nanofibrous Scaffold toward Bone Tissue Regeneration with Senescent Cells

    BiomacromoleculesJun 5, 2024

More on Reactive oxygen species

Latest