Central nervous system-active analgesics

Intervention1 paper2 findings

Humans1

Associations

2

Recurrent falls

upin humans1Low certainty

1 study

Central nervous system-active analgesics raise the risk of recurrent falls in humans (AOR: 1.30; 95% CI: 1.18-1.42).
Humanswith or at risk for knee osteoarthritis8 yearsn = 4,783
Physical Performance and Central Nervous System-Active Analgesics Independently Predict 8-Year Fall Risk in Adults with or at Risk for Knee Osteoarthritis · Archives of physical medicine and rehabilitation · 27 Sep 2026

Falls

upin humans1Low certainty

1 study

Central nervous system-active analgesics raise the risk of falls in humans (AOR: 1.16; 95% CI: 1.08-1.24).
Humanswith or at risk for knee osteoarthritis8 yearsn = 4,783
Physical Performance and Central Nervous System-Active Analgesics Independently Predict 8-Year Fall Risk in Adults with or at Risk for Knee Osteoarthritis · Archives of physical medicine and rehabilitation · 27 Sep 2026

Latest

1

Archives of Physical Medicine and RehabilitationHumans28 Sep

Physical Performance and Central Nervous System-Active Analgesics Independently Predict 8-Year Fall Risk in Adults with or at Risk for Knee Osteoarthritis