Cdk4/6 inhibitors

1. Cdk4/6 inhibitors induce cellular senescence in humans.

   “show promise in melanoma by inducing tumor senescence, modulating the tumor microenvironment, and enhancing patient immune responses.”

   Reviewin melanoma

   Advances in Cutaneous Melanoma Therapy: The Emerging Role of CDK4/6 Inhibitors

   Pharmacological research·16 Sep 2025

2. Cdk4/6 inhibitors induce cellular senescence in human cells.

   “prostate cancer cells adopt a senescent phenotype upon CDK4/6 inhibition that can be selectively targeted using senolytic compounds”

   Cellsin prostate cancer cells

   Harnessing Senolytics and PARP Inhibition to Expand the Antitumor Activity of CDK4/6 Inhibitors in Prostate Cancer

   Molecular cancer therapeutics·2 Jul 2025

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1. Cdk4/6 inhibitors decrease liver fibrosis in mice.

   “IRF3 global knockout or conditional deletion in HSCs aggravated liver fibrosis, a process mitigated by the CDK4/6 inhibitor.”

   Animalsin murine models of liver fibrosis with IRF3 deficiencyliver

   IRF3 activates RB to authorize cGAS-STING-induced senescence and mitigate liver fibrosis

   Science advances·28 Feb 2024

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