Cardiomyocyte-specific TRAF1 knockdown

Cardiomyocyte-specific TRAF1 knockdown has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest story, Nov 13, 2026: “Lowering a protein improved heart relaxation in aged mice”.

Intervention

1 paper studies it4 findingsUpdated Nov 13, 2026

1 new paper in 30 daysSee all 1 papers on cardiomyocyte-specific TRAF1 knockdown

At a glance

The findings reach mice, none yet in people. 1 lab.

None of its findings points the other way.

1 lab

Animals1

What did studies of cardiomyocyte-specific TRAF1 knockdown find?

Studies of cardiomyocyte-specific TRAF1 knockdown measured 4 outcomes, among them diastolic function, cardiac hypertrophy and cardiac inflammatory macrophage infiltration.

Diastolic function

upin mice1

1 study

Cardiomyocyte-specific TRAF1 knockdown improves diastolic function in mice (naturally aged mice).
“improved diastolic function (reduced E/A and E/e′ ratios) without affecting ejection fraction.”
Animalsnaturally aged miceAAV9 carrying a cTnT promoter-driven shTRAF1 constructheart
Lowering a protein improved heart relaxation in aged mice
Cell biology and toxicologyNov 13, 2026

Cardiac hypertrophy

downin mice1

1 study

Cardiomyocyte-specific TRAF1 knockdown decreases cardiac hypertrophy in mice (naturally aged mice).
“attenuated cardiac hypertrophy, and improved diastolic function”
Animalsnaturally aged miceAAV9 carrying a cTnT promoter-driven shTRAF1 constructheart
Lowering a protein improved heart relaxation in aged mice
Cell biology and toxicologyNov 13, 2026

Cardiac inflammatory macrophage infiltration

downin mice1

1 study

Cardiomyocyte-specific TRAF1 knockdown decreases cardiac inflammatory macrophage infiltration in mice (naturally aged mice).
“cardiomyocyte-specific TRAF1 knockdown in naturally aged mice reduced cardiac ROS levels, cardiac inflammatory macrophage infiltration, and serum pro-inflammatory cytokines”
Animalsnaturally aged miceAAV9 carrying a cTnT promoter-driven shTRAF1 constructheart
Lowering a protein improved heart relaxation in aged mice
Cell biology and toxicologyNov 13, 2026

Cardiac reactive oxygen species

downin mice1

1 study

Cardiomyocyte-specific TRAF1 knockdown decreases cardiac reactive oxygen species in mice (naturally aged mice).
“cardiomyocyte-specific TRAF1 knockdown in naturally aged mice reduced cardiac ROS levels”
Animalsnaturally aged miceAAV9 carrying a cTnT promoter-driven shTRAF1 constructheart
Lowering a protein improved heart relaxation in aged mice
Cell biology and toxicologyNov 13, 2026

Latest

1 paper in 12 months

Cell Biology and ToxicologyNov 13

Lowering a protein improved heart relaxation in aged mice

Mice given a heart-cell-targeted gene-silencing injection at 90 weeks had less inflammation and better heart relaxation when assessed at 110 weeks.Mice given a heart-cell-targeted gene-silencing injection at 90 weeks had less inflammation and better heart relaxation when assessed at 110 weeks.

Mouse studyMechanisms

Paper

Cardiomyocyte-specific TRAF1 knockdown

At a glance

What did studies of cardiomyocyte-specific TRAF1 knockdown find?

Latest

Lowering a protein improved heart relaxation in aged mice

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