Cardiac-derived extracellular vesicles

Intervention

1 paper2 findings

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Humans1

Outcomes

2

Cellular senescence

upin mice1

1 study
  1. Cardiac-derived extracellular vesicles induce cellular senescence in mice.

    “impaired memory and induced neuronal senescence.”

    Animalsaged cardiac EVs (Oc-EVs)hippocampus

    Cardiac-derived extracellular vesicles carrying miR-4433b-3p accelerate cognitive decline and brain aging by suppressing TP53INP2-mediated neuronal autophagy in mice

    Communications biology4 Jun 2026

More on Cellular senescence

Memory

downin mice1

1 study
  1. Cardiac-derived extracellular vesicles impair memory in mice.

    “Functionally, aged cardiac EVs (Oc-EVs) accumulated in the hippocampus, impaired memory and induced neuronal senescence.”

    Animalsaged cardiac EVs (Oc-EVs)brain

    Cardiac-derived extracellular vesicles carrying miR-4433b-3p accelerate cognitive decline and brain aging by suppressing TP53INP2-mediated neuronal autophagy in mice

    Communications biology4 Jun 2026

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