AgingResearch.NewsJoin free

Canine ghrh-encoding plasmid

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • 1 finding against
  • Funders: Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University and 1 more
  • Animals1

Outcomes

4

Serum IGF-1

upin dogs1no changein dogs1

1 study

  1. Canine ghrh-encoding plasmid increases serum IGF-1 in dogs.

    “post-hoc stratification revealed that dogs with low baseline IGF-1 (<90 ng/mL) showed substantial increases”

    Animalspost-hoc subgroup with baseline IGF-1 <90 ng/mLplasmid delivered by electroporationserumsingle injection180 days

    Wellness-enhancing effects of the canine growth hormone releasing hormone therapy mediated by plasmid and electroporation in healthy old dogs

    Frontiers in veterinary science15 Sep 2025

  2. Canine ghrh-encoding plasmid has no effect on serum IGF-1 in dogs.

    “While mean serum IGF-1 concentrations did not change overall”

    Animalsoverall cohort of healthy senior dogsplasmid delivered by electroporationserumsingle injection180 daysn = 30

    Wellness-enhancing effects of the canine growth hormone releasing hormone therapy mediated by plasmid and electroporation in healthy old dogs

    Frontiers in veterinary science15 Sep 2025

More on Serum IGF-1

Total CD3+ T cells and naïve CD4+ and CD8+ T cell subsets

upin dogs1

1 study

  1. Canine ghrh-encoding plasmid increases total CD3+ T cells and naïve CD4+ and CD8+ T cell subsets in dogs.

    “Flow cytometry demonstrated increases in total CD3+ T cells, as well as naïve CD4+ and CD8+ T cell subsets”

    Animalshealthy senior dogsplasmid delivered by electroporationsingle injection180 daysn = 30

    Wellness-enhancing effects of the canine growth hormone releasing hormone therapy mediated by plasmid and electroporation in healthy old dogs

    Frontiers in veterinary science15 Sep 2025

More on Total CD3+ T cells and naïve CD4+ and CD8+ T cell subsets

Hindlimb thickness

upin dogs1

1 study

  1. Canine ghrh-encoding plasmid increases hindlimb thickness in dogs.

    “Limb thickness, used as a surrogate for muscle mass, significantly increased in both hindlimbs by day 180.”

    Animalshealthy senior dogs; uncontrolled before-and-after assessmentplasmid delivered by electroporationhindlimbsingle injection180 daysn = 30

    Wellness-enhancing effects of the canine growth hormone releasing hormone therapy mediated by plasmid and electroporation in healthy old dogs

    Frontiers in veterinary science15 Sep 2025

Owner-assessed well-being

upin dogs1+90% dogs showed increased well-being

1 study

  1. Canine ghrh-encoding plasmid improves owner-assessed well-being in dogs (90% of dogs showed increased well-being).

    “Significant improvements were observed in clinical scores, with 90% of dogs showing increased well-being based on owner-assessed measures including appetite, activity, and exercise tolerance.”

    Animalshealthy senior dogs; uncontrolled before-and-after assessmentplasmid delivered by electroporationsingle injection180 daysn = 30

    Wellness-enhancing effects of the canine growth hormone releasing hormone therapy mediated by plasmid and electroporation in healthy old dogs

    Frontiers in veterinary science15 Sep 2025

Latest

Related