Science Advances
SATB1 loss reshapes 3D genome in mouse naive T cells
Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene expression during aging.Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene expression during aging.
Experiments in miceBlood and immune system