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Levodopa + carbidopa + canagliflozin

Levodopa + carbidopa + canagliflozin has been studied in 1 paper since 2024: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Oct 14, 2024: “Targeting the Sirtuin-1/PPAR-Gamma Axis, RAGE/HMGB1/NF-κB Signaling, and the Mitochondrial Functions by Canagliflozin Augments the Protective Effects of Levodopa/Carbidopa in Rotenone-Induced Parkinson's Disease”.

Intervention

1 paper studies it4 findingsUpdated

See all 1 papers on levodopa + carbidopa + canagliflozin

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Mice: a single group. Cells, worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Taif University
  • Animals1

What did studies of levodopa + carbidopa + canagliflozin find?

4

Studies of levodopa + carbidopa + canagliflozin measured 4 outcomes, among them rotenone-induced histomorphologic changes, neuroinflammatory responses and striatal dopamine.

Rotenone-induced histomorphologic changes

downin mice1

1 study

  1. Levodopa + carbidopa + canagliflozin decreases rotenone-induced histomorphologic changes in mice (rotenone-induced parkinsonism).

    “alleviated the histomorphologic changes induced by rotenone administration”

    Animalsrotenone-induced parkinsonismstriatum

    Targeting the Sirtuin-1/PPAR-Gamma Axis, RAGE/HMGB1/NF-κB Signaling, and the Mitochondrial Functions by Canagliflozin Augments the Protective Effects of Levodopa/Carbidopa in Rotenone-Induced Parkinson's Disease

    Medicina (Kaunas, Lithuania)

neuroinflammatory responses

downin mice1

1 study

  1. Levodopa + carbidopa + canagliflozin decreases neuroinflammatory responses in mice (rotenone-induced parkinsonism).

    “abrogated the neuroinflammatory responses”

    Animalsrotenone-induced parkinsonism

    Targeting the Sirtuin-1/PPAR-Gamma Axis, RAGE/HMGB1/NF-κB Signaling, and the Mitochondrial Functions by Canagliflozin Augments the Protective Effects of Levodopa/Carbidopa in Rotenone-Induced Parkinson's Disease

    Medicina (Kaunas, Lithuania)

Striatal dopamine

upin mice1

1 study

  1. Levodopa + carbidopa + canagliflozin increases striatal dopamine in mice (rotenone-induced parkinsonism).

    “The combination of levodopa/carbidopa and canagliflozin significantly mitigated the changes induced by rotenone administration regarding the behavioral tests, striatal dopamine”

    Animalsrotenone-induced parkinsonismstriatum

    Targeting the Sirtuin-1/PPAR-Gamma Axis, RAGE/HMGB1/NF-κB Signaling, and the Mitochondrial Functions by Canagliflozin Augments the Protective Effects of Levodopa/Carbidopa in Rotenone-Induced Parkinson's Disease

    Medicina (Kaunas, Lithuania)

More on Striatal dopamine

Rotenone-induced behavioral changes

downin mice1

1 study

  1. Levodopa + carbidopa + canagliflozin decreases rotenone-induced behavioral changes in mice (rotenone-induced parkinsonism).

    “The combination of levodopa/carbidopa and canagliflozin significantly mitigated the changes induced by rotenone administration regarding the behavioral tests”

    Animalsrotenone-induced parkinsonism

    Targeting the Sirtuin-1/PPAR-Gamma Axis, RAGE/HMGB1/NF-κB Signaling, and the Mitochondrial Functions by Canagliflozin Augments the Protective Effects of Levodopa/Carbidopa in Rotenone-Induced Parkinson's Disease

    Medicina (Kaunas, Lithuania)

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