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Calorie-restricted dash diet

Intervention

2 papers8 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: South Dakota State University and 2 more
  • Human trial2

Outcomes

8

IGF-1

upin humans1

1 study

  1. Calorie-restricted dash diet increases IGF-1 in humans (p < 0.001).

    “IGF-1 (p < 0.001) and IL-8 (p = 0.005) increased in response to the intervention.”

    Human trialsedentary obese older adultsblood12-weeksn = 28

    Cardiometabolic Changes in Response to a Calorie-Restricted DASH Diet in Obese Older Adults

    Frontiers in nutrition19 Mar 2021

More on IGF-1

C-reactive protein

downin humans1

1 study

  1. Calorie-restricted dash diet decreases C-reactive protein in humans (p = 0.006).

    “IL-12 (p < 0.001), and CRP (p = 0.006) all decreased in response to the study diet.”

    Human trialsedentary obese older adultsblood12-weeksn = 28

    Cardiometabolic Changes in Response to a Calorie-Restricted DASH Diet in Obese Older Adults

    Frontiers in nutrition19 Mar 2021

More on C-reactive protein

HOMA-IR

downin humans1

1 study

  1. Calorie-restricted dash diet decreases HOMA-IR in humans (p < 0.05).

    “insulin (p = 0.014), glucose (p = 0.008), HOMA-IR (p < 0.05), IL-12 (p < 0.001), and CRP (p = 0.006) all decreased in response to the study diet.”

    Human trialsedentary obese older adultsblood12-weeksn = 28

    Cardiometabolic Changes in Response to a Calorie-Restricted DASH Diet in Obese Older Adults

    Frontiers in nutrition19 Mar 2021

More on HOMA-IR

Total cholesterol

downin humans1

1 study

  1. Calorie-restricted dash diet decreases total cholesterol in humans (p < 0.001).

    “Total cholesterol (p < 0.001), LDL-C (p = 0.004), HDL-C (p < 0.0001), insulin (p = 0.014), glucose (p = 0.008), HOMA-IR (p < 0.05), IL-12 (p < 0.001), and CRP (p = 0.006) all decreased in response to the study diet.”

    Human trialsedentary obese older adultsblood12-weeksn = 28

    Cardiometabolic Changes in Response to a Calorie-Restricted DASH Diet in Obese Older Adults

    Frontiers in nutrition19 Mar 2021

More on Total cholesterol

Handgrip strength

no changein humans1

1 study

  1. Calorie-restricted dash diet has no effect on handgrip strength in humans (p > 0.05).

    “Handgrip strength, gait, balance, and resting energy expenditure (REE) were well maintained (p > 0.05) throughout the study.”

    Human trialobese12 weeksn = 36

    A Calorie-Restricted DASH Diet Reduces Body Fat and Maintains Muscle Strength in Obese Older Adults

    Nutrients30 Dec 2019

Sit-to-stand performance

upin humans1

1 study

  1. Calorie-restricted dash diet improves sit-to-stand performance in humans (p < 0.001).

    “Significant effects of the study diet were detected across time for sit/stand (p < 0.001) such that an increase was observed.”

    Human trialobese12 weeksn = 36

    A Calorie-Restricted DASH Diet Reduces Body Fat and Maintains Muscle Strength in Obese Older Adults

    Nutrients30 Dec 2019

Fat mass

downin humans1

1 study

  1. Calorie-restricted dash diet decreases fat mass in humans (-4.4 kg).

    “absolute fat mass (AFM) decreased by 4.4 kg (p < 0.001)”

    Human trialobese12 weeksn = 36

    A Calorie-Restricted DASH Diet Reduces Body Fat and Maintains Muscle Strength in Obese Older Adults

    Nutrients30 Dec 2019

Body weight

downin humans1−6.3%

1 study

  1. Calorie-restricted dash diet decreases body weight in humans (-6.3%).

    “From baseline to study end, total body weight decreased by 6.3% (p < 0.001)”

    Human trialobese12 weeksn = 36

    A Calorie-Restricted DASH Diet Reduces Body Fat and Maintains Muscle Strength in Obese Older Adults

    Nutrients30 Dec 2019

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