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Bpv

Intervention

1 paper studies it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 1 more
  • Animals1

Outcomes

2

PI3K–AKT signaling

upin mice1

1 study

  1. Bpv activates PI3K–AKT signaling in mice.

    “Pharmacological treatment with the PTEN (phosphatase and tensin homolog deleted on chromosome 10) inhibitor bpV (HOpic) increases Akt activity and improves multiple abnormalities in Zmpste24-deficient mice.”

    Animalsin Zmpste24-deficient mice

    Progerin modulates the IGF-1R/Akt signaling involved in aging

    Science advancesJul 8, 2022

More on PI3K–AKT signaling

Multiple abnormalities

upin mice1

1 study

  1. Bpv improves multiple abnormalities in mice.

    “Pharmacological treatment with the PTEN (phosphatase and tensin homolog deleted on chromosome 10) inhibitor bpV (HOpic) increases Akt activity and improves multiple abnormalities in Zmpste24-deficient mice.”

    Animalsin Zmpste24-deficient mice

    Progerin modulates the IGF-1R/Akt signaling involved in aging

    Science advancesJul 8, 2022

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