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Beta-alanine, 4-guanidinobutanoic acid, 4-hydroxyproline, pantothenic acid

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Institutes of Health and 2 more
  • Animals1

Outcomes

1

Mitochondrial protection

upin worms1

1 study

  1. Beta-alanine, 4-guanidinobutanoic acid, 4-hydroxyproline, pantothenic acid increases mitochondrial protection in worms.

    “four metabolite candidates (beta-alanine, 4-guanidinobutanoic acid, 4-hydroxyproline, pantothenic acid) that, when supplemented in C. elegans provided robust gero- and mitochondrial protection.”

    Model organisms

    Metabolic analysis of sarcopenic muscle identifies positive modulators of longevity and healthspan in C. elegans

    Redox biology14 Jun 2025

Associations

1

Lifespan and healthspan

mixedin worms1

1 study

  1. Beta-alanine, 4-guanidinobutanoic acid, 4-hydroxyproline, pantothenic acid is associated with lifespan and healthspan in worms.

    “These candidates also affected life-, and health- span in C. elegans models of amyotrophic lateral sclerosis (ALS) and Duchenne muscular dystrophy (DMD).”

    Model organismsmodels of amyotrophic lateral sclerosis and Duchenne muscular dystrophy

    Metabolic analysis of sarcopenic muscle identifies positive modulators of longevity and healthspan in C. elegans

    Redox biology14 Jun 2025

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