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BAY2416964

Intervention

1 paper3 findings

PubChem 135303769

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Augusta University and 6 more
  • Animals1

Outcomes

3

Cortical bone mass

upin mice1

1 study

  1. BAY2416964 increases cortical bone mass in mice.

    “Cortical bone mass was also greater in BAY- than VEH-treated mice.”

    AnimalsCompared with vehicle-treated C57BL/6 micecortical bone30 mg/kg, 5 days/week8 weeksfemales

    Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions

    JCI insight15 Jul 2025

Neuromuscular junction integrity

upin mice1

1 study

  1. BAY2416964 improves neuromuscular junction integrity in mice.

    “BAY preserved grip strength in part by improving integrity of neuromuscular junctions (NMJs)”

    AnimalsC57BL/6 miceneuromuscular junction30 mg/kg, 5 days/week8 weeksfemales

    Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions

    JCI insight15 Jul 2025

Grip strength

downin mice1

1 study

  1. BAY2416964 protects against grip strength in mice.

    “While grip strength declined over time in VEH-treated mice, BAY preserved grip strength in part by improving integrity of neuromuscular junctions (NMJs)”

    AnimalsCompared with vehicle-treated C57BL/6 mice30 mg/kg, 5 days/week8 weeksfemales

    Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions

    JCI insight15 Jul 2025

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