Atractylenolide iii

1. Atractylenolide iii has no effect on body weight in mice.

   “without overt short-term changes in body weight or major-organ histology.”

   Animalsnatural aging10 or 20 mg/kg/day1 monthmales

   Atractylenolide III attenuates age-related vertebral bone loss by suppressing macrophage inflammation and osteoclastogenesis

   Bone reports·2 Oct 2026

1. Atractylenolide iii improves vertebral microarchitecture in mice.

   “AT-III-treated aged mice showed improved vertebral microarchitecture, increased osteoblast surface, and reduced osteoclast and eroded-surface indices”

   Animalsnatural agingvertebral bone10 or 20 mg/kg/day1 monthmales

   Atractylenolide III attenuates age-related vertebral bone loss by suppressing macrophage inflammation and osteoclastogenesis

   Bone reports·2 Oct 2026

1. Atractylenolide iii decreases osteoclast formation in mouse cells.

   “and suppressed RANKL-induced osteoclast formation.”

   CellsRANKL-induced osteoclastogenesisbone marrow-derived macrophage

   Atractylenolide III attenuates age-related vertebral bone loss by suppressing macrophage inflammation and osteoclastogenesis

   Bone reports·2 Oct 2026

1. Atractylenolide iii decreases TNF-α and IL-1β secretion in mouse cells.

   “In aged bone marrow-derived macrophages, AT-III reduced TNF-α and IL-1β secretion”

   Cellsbone marrow-derived macrophage

   Atractylenolide III attenuates age-related vertebral bone loss by suppressing macrophage inflammation and osteoclastogenesis

   Bone reports·2 Oct 2026

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