Asiaticoside

1. Asiaticoside decreases cellular senescence in human cells.

   “In vitro, AC ameliorated high glucose-induced endothelial cell senescence”

   Cellshigh glucose (35 mM)human microvascular endothelial cell

   Asiaticoside attenuates endothelial cells senescence in diabetic retinopathy via CCND1-mediated mitophagy through the PI3K/AKT/mTOR pathway

   Journal of ethnopharmacology·1 Aug 2026

2. Asiaticoside inhibits cellular senescence in mice.

   “Treatment with ASI alleviated mesothelial cell senescence and prevented PF in vivo.”

   Animalsperitoneal fibrosismesothelial cell

   Asiaticoside alleviates mesothelial cell senescence and peritoneal fibrosis by targeting macrophage-mesothelial communication in single-cell peritoneal landscape

   Phytomedicine : international journal of phytotherapy and phytopharmacology·23 May 2026

More on Cellular senescence

1. Asiaticoside inhibits PI3K–AKT signalling in human cells.

   “Mechanistically, AC treatment or CCND1 knockdown inhibited high glucose-induced activation of the PI3K-AKT-mTOR signaling pathway”

   Cellshigh glucose (35 mM)human microvascular endothelial cell

   Asiaticoside attenuates endothelial cells senescence in diabetic retinopathy via CCND1-mediated mitophagy through the PI3K/AKT/mTOR pathway

   Journal of ethnopharmacology·1 Aug 2026

More on PI3K–AKT signalling

1. Asiaticoside induces mitophagy in human cells.

   “AC ameliorated high glucose-induced endothelial cell senescence, attenuated cellular and mitochondrial dysfunction as well as reactive oxygen species (ROS) production, and induced mitophagy.”

   Cellshigh glucose (35 mM)human microvascular endothelial cell

   Asiaticoside attenuates endothelial cells senescence in diabetic retinopathy via CCND1-mediated mitophagy through the PI3K/AKT/mTOR pathway

   Journal of ethnopharmacology·1 Aug 2026

More on Mitophagy

1. Asiaticoside decreases retinal vascular leakage in mice.

   “AC treatment significantly lowered the visual contrast threshold by approximately 18% and reduced retinal vascular leakage in diabetic mice.”

   Animalsstreptozotocin-induced diabetesretina

   Asiaticoside attenuates endothelial cells senescence in diabetic retinopathy via CCND1-mediated mitophagy through the PI3K/AKT/mTOR pathway

   Journal of ethnopharmacology·1 Aug 2026

1. Asiaticoside decreases visual contrast threshold in mice (approximately 18% lower).

   “AC treatment significantly lowered the visual contrast threshold by approximately 18% and reduced retinal vascular leakage in diabetic mice.”

   Animalsstreptozotocin-induced diabetes

   Asiaticoside attenuates endothelial cells senescence in diabetic retinopathy via CCND1-mediated mitophagy through the PI3K/AKT/mTOR pathway

   Journal of ethnopharmacology·1 Aug 2026

1. Asiaticoside activates insulin/IGF-1 signalling in mice.

   “ASI inhibited mesothelial cell senescence by enhancing IGF1 signaling in macrophages-mesothelial communication.”

   Animalsperitoneal fibrosismacrophage and mesothelial cell

   Asiaticoside alleviates mesothelial cell senescence and peritoneal fibrosis by targeting macrophage-mesothelial communication in single-cell peritoneal landscape

   Phytomedicine : international journal of phytotherapy and phytopharmacology·23 May 2026

More on Insulin/IGF-1 signalling

1. Asiaticoside prevents peritoneal fibrosis in mice.

   “Treatment with ASI alleviated mesothelial cell senescence and prevented PF in vivo.”

   Animalshigh-glucose peritoneal dialysis fluid-induced modelperitoneum

   Asiaticoside alleviates mesothelial cell senescence and peritoneal fibrosis by targeting macrophage-mesothelial communication in single-cell peritoneal landscape

   Phytomedicine : international journal of phytotherapy and phytopharmacology·23 May 2026

More on Peritoneal fibrosis