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Anti-il-1β antibody

Intervention

3 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Fondation Leducq and 4 more
  • Humans1
  • Animals1

Outcomes

3

Sepsis symptoms

downin mice1

1 study

  1. Anti-il-1β antibody decreases sepsis symptoms in mice.

    “Treatment with NLRP3 inhibition (MCC950) and antibodies against IL-18 and IL-1β alleviated sepsis symptoms in aged mice”

    Animalscecal ligation and puncture-induced sepsis

    The role and mechanism of the NLRP3-IL-1β/IL-18 signaling axis in the progression of sepsis under an aging phenotype

    Life sciencesJun 16, 2025

Cellular senescence

upin mice1

1 study

  1. Anti-il-1β antibody increases cellular senescence in mice.

    “increasedintraplaque hemorrhage, necrotic core area, and senescence as compared with IgG control antibody-treated mice.”

    Animalsafter diet-induced reductions in lipids in Apoe-/- mice8 weeks

    IL-1β Inhibition Partially Negates the Beneficial Effects of Diet-Induced Atherosclerosis Regression in Mice

    Arteriosclerosis, thrombosis, and vascular biologyMay 2, 2024

More on Cellular senescence

Atherosclerotic plaque burden

upin mice1

1 study

  1. Anti-il-1β antibody increases atherosclerotic plaque burden in mice.

    “IL-1β antibody treatment after diet-induced reductions in lipids resulted in multiple detrimental changes including increased plaque burden and brachiocephalic artery lesion size”

    Animalsafter diet-induced reductions in lipids in Apoe-/- mice8 weeks

    IL-1β Inhibition Partially Negates the Beneficial Effects of Diet-Induced Atherosclerosis Regression in Mice

    Arteriosclerosis, thrombosis, and vascular biologyMay 2, 2024

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