Aminophylline

1. Aminophylline inhibits cell growth in yeast cells.

   “Our platform also identifies the caffeine analog aminophylline as a TOR1-dependent growth inhibitor via selective tor1 growth sensitivity.”

   Cellsvia selective tor1 growth sensitivity

   An mTOR inhibitor discovery system using drug-sensitized yeast

   GeroScience·Jan 30, 2025

1. Aminophylline inhibits growth in yeast cells.

   “Our platform also identifies the caffeine analog aminophylline as a TOR1 -dependent growth inhibitor via selective tor1 growth sensitivity.”

   Cellsin drug-sensitized yeast background

   An mTOR Inhibitor Discovery System Using the Growth of Drug-Sensitized Yeast Strains

   bioRxiv (Cold Spring Harbor Laboratory)·Jan 4, 2025Preprint

1. Aminophylline activates autophagy in rats.

   “Aminophylline suppresses chronic renal failure progression by modulating the SIRT1/AMPK/mTOR-mediated autophagy process.”

   Animalsin CRF ratskidney

   Aminophylline suppresses chronic renal failure progression by activating SIRT1/AMPK/mTOR-dependent autophagy

   Acta biochimica et biophysica Sinica·May 28, 2024

More on Autophagy

1. Aminophylline inhibits apoptosis in rats.

   “aminophylline alleviates apoptosis in the glomerular tissues of CRF rats.”

   Animalsin CRF ratsglomerular tissues

   Aminophylline suppresses chronic renal failure progression by activating SIRT1/AMPK/mTOR-dependent autophagy

   Acta biochimica et biophysica Sinica·May 28, 2024

More on Apoptosis

1. Aminophylline decreases renal tissue injuries in rats.

   “Histological analyses show that aminophylline effectively alleviates renal tissue injuries in CRF rats.”

   Animalsin CRF ratskidney

   Aminophylline suppresses chronic renal failure progression by activating SIRT1/AMPK/mTOR-dependent autophagy

   Acta biochimica et biophysica Sinica·May 28, 2024

1. Aminophylline decreases serum creatinine in rats.

   “Aminophylline significantly reduces the levels of SCR, UPR, and BUN in the CRF model rats.”

   Animalsin CRF ratskidney

   Aminophylline suppresses chronic renal failure progression by activating SIRT1/AMPK/mTOR-dependent autophagy

   Acta biochimica et biophysica Sinica·May 28, 2024

More on Serum creatinine