Ganoderic acid a

1. Ganoderic acid a increases osteogenic differentiation in mouse cells.

   “GAA promotes osteogenic differentiation and accelerates OF healing via ERα.”

   CellsMC3T3-E1

   Ganoderic acid A accelerates osteoporotic fracture healing by promoting osteogenic differentiation via estrogen receptor alpha binding

   Journal of orthopaedic translation·23 Jul 2026

1. Ganoderic acid a increases flexural rigidity in mice.

   “increased radiographic union, bone mineral density and flexural rigidity in OF mice.”

   Animalsovariectomized femoral fracture modelfemur

   Ganoderic acid A accelerates osteoporotic fracture healing by promoting osteogenic differentiation via estrogen receptor alpha binding

   Journal of orthopaedic translation·23 Jul 2026

1. Ganoderic acid a increases bone mineral density in mice.

   “increased radiographic union, bone mineral density and flexural rigidity in OF mice.”

   Animalsovariectomized femoral fracture modelfemur

   Ganoderic acid A accelerates osteoporotic fracture healing by promoting osteogenic differentiation via estrogen receptor alpha binding

   Journal of orthopaedic translation·23 Jul 2026

More on Bone mineral density

1. Ganoderic acid a improves physical function in mice.

   “Notably, GAA displays a capability to enhance physical function and adapts to conditional changes in metabolic demand as mice aged.”

   Animalsaged mice

   High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models

   Nature communications·24 Mar 2025

1. Ganoderic acid a decreases cellular senescence in mice.

   “Administration of GAA also mitigates the accumulation of senescent cells and physiological decline in multiple organs”

   Animals

   High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models

   Nature communications·24 Mar 2025

More on Cellular senescence

1. Ganoderic acid a improves healthspan in worms.

   “In C. elegans, GAA treatment extends lifespan and healthspan as effectively as rapamycin.”

   Model organisms

   High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models

   Nature communications·24 Mar 2025

1. Ganoderic acid a extends lifespan in worms.

   “In C. elegans, GAA treatment extends lifespan and healthspan as effectively as rapamycin.”

   Model organisms

   High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models

   Nature communications·24 Mar 2025