α-ketobutyrate
α-ketobutyrate has been studied in 4 papers since 2019: 1 observational study in people, 3 in animals. The newest paper, Jan 16, 2023: “The metabolite alpha-ketobutyrate extends lifespan by promoting peroxisomal function in C. elegans”.
None of its findings points the other way.
- 3 independent labs in 2 countries
- Funders: National Institutes of Health and others
- 2 of 8 findings with company ties
- Humans1
- Animals2
- Model organisms1
What did studies of α-ketobutyrate find?
6Studies of α-ketobutyrate measured 6 outcomes; the most studied are lifespan (2 studies), NAD+ (1) and healthspan (1).
Lifespan
upin worms2upin mice1
2 studies
Lifespan
upin worms2upin mice1
α-ketobutyrate extends lifespan in worms.
“supplementation with α-ketobutyrate, an intermediate of the transsulfuration pathway, extends lifespan in wild-type worms”
Model organisms
The metabolite alpha-ketobutyrate extends lifespan by promoting peroxisomal function in C. elegans
Nature communications
α-ketobutyrate extends lifespan in mice.
“α-KB also delays aging in mammals, increasing the lifespan of aged male mice and the healthspan of both male and female animals.”
Animalsmales
The metabolite α-ketobutyrate increases health and life spans by activating AMPK
bioRxiv (Cold Spring Harbor Laboratory)Preprint
α-ketobutyrate extends lifespan in worms.
“supplementation with the endogenous metabolite α-ketobutyrate (α-KB) increases the lifespan of adult C. elegans”
Model organisms
The metabolite α-ketobutyrate increases health and life spans by activating AMPK
bioRxiv (Cold Spring Harbor Laboratory)Preprint
NAD+
upin worms1
1 study
NAD+
upin worms1
α-ketobutyrate increases NAD+ in worms (via lactate dehydrogenase LDH-1).
“Alpha-ketobutyrate augments the production of NAD+ via the lactate dehydrogenase LDH-1”
Model organismsvia lactate dehydrogenase LDH-1
The metabolite alpha-ketobutyrate extends lifespan by promoting peroxisomal function in C. elegans
Nature communications
Healthspan
upin mice1
1 study
Healthspan
upin mice1
α-ketobutyrate improves healthspan in mice.
“α-KB also delays aging in mammals, increasing the lifespan of aged male mice and the healthspan of both male and female animals.”
Animals
The metabolite α-ketobutyrate increases health and life spans by activating AMPK
bioRxiv (Cold Spring Harbor Laboratory)Preprint
HIV latency
upin human cells1
1 study
HIV latency
upin human cells1
α-ketobutyrate increases HIV latency in vitro.
“triggered the differentiation of TGF-β producing Tregs and promoted HIV latency establishment in vitro”
Cellsin vitro
bioRxiv (Cold Spring Harbor Laboratory)Preprint
Regulatory T cell differentiation
upin human cells1
1 study
Regulatory T cell differentiation
upin human cells1
α-ketobutyrate increases regulatory T cell differentiation in vitro.
“triggered the differentiation of TGF-β producing Tregs and promoted HIV latency establishment in vitro”
Cellsin vitro
bioRxiv (Cold Spring Harbor Laboratory)Preprint
Alopecia
downin mice1
1 study
Alopecia
downin mice1
α-ketobutyrate prevents alopecia in mice (oral administration).
“oral α-KB prevents hair loss in aged mice”
Animalsoral administration
Stimulation of Hair Growth by Small Molecules that Activate Autophagy
Cell reports