ALK5 inhibitor

1. ALK5 inhibitor improves body size in mice.

   “rescued the cardiac phenotype as well as the body size of mice at birth”

   Animalsin Nipbl+/- micefrom E9.5 to E13.5

   TGFβ−induced embryonic cell senescence at the origin of the Cornelia de Lange syndrome

   bioRxiv (Cold Spring Harbor Laboratory)·Jul 27, 2022Preprint

1. ALK5 inhibitor improves cardiac malformations in mice.

   “rescued the cardiac phenotype as well as the body size of mice at birth”

   Animalsin Nipbl+/- micefrom E9.5 to E13.5

   TGFβ−induced embryonic cell senescence at the origin of the Cornelia de Lange syndrome

   bioRxiv (Cold Spring Harbor Laboratory)·Jul 27, 2022Preprint

1. ALK5 inhibitor prevents cellular senescence in mice.

   “Treatment of pregnant Nipbl+/- mice with a TGFβR (ALK5) inhibitor from E9.5 to E13.5 prevented cell -senescence”

   Animalsin Nipbl+/- mouse embryosfrom E9.5 to E13.5

   TGFβ−induced embryonic cell senescence at the origin of the Cornelia de Lange syndrome

   bioRxiv (Cold Spring Harbor Laboratory)·Jul 27, 2022Preprint

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