Oxytocin + ALK5 inhibitor
- 1 lab in 1 country
- Funders: National Institute on Aging and 7 more
- Animals2
Outcomes
5Protein noise
downin mice1
1 study
Protein noise
downin mice1
Oxytocin + ALK5 inhibitor decreases protein noise in mice.
“treatment of the old mice with OT+A5i youthfully restored systemic signaling determinants and reduced protein noise in old mice of both sexes.”
Animals7 days
Sex-specific longitudinal reversal of aging in old frail mice
AgingAug 21, 2025
Fertility
upin mice1
1 study
Fertility
upin mice1
Oxytocin + ALK5 inhibitor improves fertility in mice.
“yet OT+A5i had positive effects on fertility of middle-aged female mice.”
Animalsfemales
Sex-specific longitudinal reversal of aging in old frail mice
AgingAug 21, 2025
Healthspan
upin mice1
1 study
Healthspan
upin mice1
Oxytocin + ALK5 inhibitor improves healthspan in mice.
“Further, these animals had significantly increased healthspan, with improved physical performance, endurance, short term memory, and resilience to mortality.”
Animalsfrailmales
Sex-specific longitudinal reversal of aging in old frail mice
AgingAug 21, 2025
Lifespan
upin mice1+14% overall median lifespan
1 study
Lifespan
upin mice1+14% overall median lifespan
Oxytocin + ALK5 inhibitor extends lifespan in mice (+14% overall median lifespan).
“Treatment of old frail male mice with OT+A5i resulted in a remarkable 73% life extension from that time, and a 14% increase in the overall median lifespan.”
Animalsfrailmales
Sex-specific longitudinal reversal of aging in old frail mice
AgingAug 21, 2025
Muscle pathology
downin mice1
1 study
Muscle pathology
downin mice1
Oxytocin + ALK5 inhibitor protects against muscle pathology in mice.
“allowed aged mice to exercise without pathologies of skeletal and heart muscles and youthfully restored their de novo proteomes.”
Animalsduring exerciseskeletal and heart muscles
In Old Mice, Exercise Induces Inflammation and Fibrosis Unless Alk5-Inhibitor and Oxytocin Are Used
Journal of cellular physiologyJun 1, 2025