Alfatradiol

9 papers study it7 findingsUpdated Mar 14, 2024

None of its findings points the other way.

What did studies of Alfatradiol find?

Studies of Alfatradiol measured 7 outcomes; the most studied are healthspan (1 study), lifespan (1) and dna synthesis (1).

Healthspan

upin mice1

1 study

Alfatradiol improves healthspan in mice.
“Notably, 17αE2 treatment improved outcomes in a genotype-dependent manner favoring APOE4 mice.”
AnimalsAPOE4 knock-in mice20 weeksmales
Protection against APOE4 -associated aging phenotypes with the longevity-promoting intervention 17α-estradiol in male mice
bioRxiv : the preprint server for biologyMar 14, 2024Preprint

Lifespan

upin mice1

1 study

Alfatradiol extends lifespan in mice.
“17α-Estradiol (17α-E2) is a "non-feminizing" estrogen that extends life span in male, but not female, mice.”
Reviewmales
Short-term Calorie Restriction and 17α-Estradiol Administration Elicit Divergent Effects on Proteostatic Processes and Protein Content in Metabolically Active Tissues
The journals of gerontology. Series A, Biological sciences and medical sciencesApr 17, 2020

dna synthesis

no changein mice1

1 study

Alfatradiol has no effect on dna synthesis in mice.
“17α-E2 had no effect on protein synthesis or DNA synthesis in multiple tissues, including white adipose tissue.”
Animalsmales
Short-term Calorie Restriction and 17α-Estradiol Administration Elicit Divergent Effects on Proteostatic Processes and Protein Content in Metabolically Active Tissues
The journals of gerontology. Series A, Biological sciences and medical sciencesApr 17, 2020

protein synthesis

no changein mice1

1 study

Alfatradiol has no effect on protein synthesis in mice.
“17α-E2 had no effect on protein synthesis or DNA synthesis in multiple tissues, including white adipose tissue.”
Animalsmales
Short-term Calorie Restriction and 17α-Estradiol Administration Elicit Divergent Effects on Proteostatic Processes and Protein Content in Metabolically Active Tissues
The journals of gerontology. Series A, Biological sciences and medical sciencesApr 17, 2020

Amyloid-beta

downin mice1−38%

1 study

Alfatradiol decreases amyloid-beta in mice (-38%).
“levels of Abeta were decreased by 27% and 38% in mice treated with 17beta- and 17alpha- estradiol, respectively”
AnimalsSwedish mutant AbetaPP transgenic ovariectomized micepelletbrainfemales
17Alpha-estradiol and 17beta-estradiol treatments are effective in lowering cerebral amyloid-beta levels in AbetaPPSWE transgenic mice
Journal of Alzheimer's disease : JADDec 1, 2002