Aged small intestinal epithelium-derived exosomes
1 paper3 findings
- 1 lab in 1 country
- Funder: National Natural Science Foundation of China
- Animals1
Outcomes
3Cellular senescence
upin mouse cells1
1 study
Cellular senescence
upin mouse cells1
Aged small intestinal epithelium-derived exosomes induce cellular senescence in mouse cells.
“In vitro studies revealed that aged SI-exos could induce the activation and senescence of young CFs”
Cellsyoung CFs
Exosomes from small intestinal epithelium mediate cardiac fibrosis during aging
The journals of gerontology. Series A, Biological sciences and medical sciences18 Aug 2025
Cardiac function
downin mice1
1 study
Cardiac function
downin mice1
Aged small intestinal epithelium-derived exosomes impair cardiac function in mice.
“Systemic administration of aged SI-exos exerted deleterious effects on the hearts of young recipient mice, as evidenced by exacerbated cardiac aging, inflammation, fibrosis, and the resulting poorer cardiac function.”
Animalsheart
Exosomes from small intestinal epithelium mediate cardiac fibrosis during aging
The journals of gerontology. Series A, Biological sciences and medical sciences18 Aug 2025
Cardiac fibrosis
upin mice1
1 study
Cardiac fibrosis
upin mice1
Aged small intestinal epithelium-derived exosomes increase cardiac fibrosis in mice.
“Systemic administration of aged SI-exos exerted deleterious effects on the hearts of young recipient mice, as evidenced by exacerbated cardiac aging, inflammation, fibrosis, and the resulting poorer cardiac function.”
Animalsyoung recipient mice
Exosomes from small intestinal epithelium mediate cardiac fibrosis during aging
The journals of gerontology. Series A, Biological sciences and medical sciences18 Aug 2025