Adipose-derived progenitor cell exosomes

1. Adipose-derived progenitor cell exosomes inhibit cellular senescence in human cells.

   “Notably, yAPC-Exos exerted more pronounced anti-senescent effects than oAPC-Exos.”

   Cellsin senescent human dermal fibroblasts

   Exosomes from APCs ameliorate human skin fibroblast senescence via p53/p21 signaling pathway

   Tissue & cell·30 Jan 2026

More on Cellular senescence

1. Adipose-derived progenitor cell exosomes increase SIRT1 in human cells.

   “These effects occurred primarily through p21 and p53 downregulation and SIRT1 upregulation.”

   Cellsin senescent human dermal fibroblasts

   Exosomes from APCs ameliorate human skin fibroblast senescence via p53/p21 signaling pathway

   Tissue & cell·30 Jan 2026

More on SIRT1

1. Adipose-derived progenitor cell exosomes decrease CDKN1A in human cells.

   “These effects occurred primarily through p21 and p53 downregulation and SIRT1 upregulation.”

   Cellsin senescent human dermal fibroblasts

   Exosomes from APCs ameliorate human skin fibroblast senescence via p53/p21 signaling pathway

   Tissue & cell·30 Jan 2026

More on CDKN1A

1. Adipose-derived progenitor cell exosomes decrease TP53 in human cells.

   “These effects occurred primarily through p21 and p53 downregulation and SIRT1 upregulation.”

   Cellsin senescent human dermal fibroblasts

   Exosomes from APCs ameliorate human skin fibroblast senescence via p53/p21 signaling pathway

   Tissue & cell·30 Jan 2026

More on TP53

1. Adipose-derived progenitor cell exosomes decrease reactive oxygen species in human cells.

   “Exosome treatment decreased intracellular reactive oxygen species levels and alleviated aging-associated phenotypes in senescent HDFs.”

   Cellsin senescent human dermal fibroblasts

   Exosomes from APCs ameliorate human skin fibroblast senescence via p53/p21 signaling pathway

   Tissue & cell·30 Jan 2026

More on Reactive oxygen species