Acrolein

2 papers4 findings

1 lab in 1 country

Funders: National Key Research and Development Program of China and 1 more

Humans1
Model organisms1

Outcomes

4

Oxidative stress and ROS signaling

upin worms1

1 study

Acrolein induces oxidative stress and ROS signaling in worms.
“ACR significantly enhanced the endogenous ROS levels of C. elegans, inhibited the antioxidant-related enzyme activities”
Model organisms
Acrolein Promotes Aging and Oxidative Stress via the Stress Response Factor DAF-16/FOXO in Caenorhabditis elegans
Foods (Basel, Switzerland)May 28, 2022

More on Oxidative stress and ROS signaling

Reproductive capacity

downin worms1

1 study

Acrolein decreases reproductive capacity in worms.
“The reproductive capacity, body length, body width, and locomotive behavior (head thrash) of C. elegans were diminished by ACR”
Model organisms12.5-100 μM
Acrolein Promotes Aging and Oxidative Stress via the Stress Response Factor DAF-16/FOXO in Caenorhabditis elegans
Foods (Basel, Switzerland)May 28, 2022

Locomotive behavior

downin worms1

1 study

Acrolein impairs locomotive behavior in worms.
“The reproductive capacity, body length, body width, and locomotive behavior (head thrash) of C. elegans were diminished by ACR”
Model organisms50 and 100 μM
Acrolein Promotes Aging and Oxidative Stress via the Stress Response Factor DAF-16/FOXO in Caenorhabditis elegans
Foods (Basel, Switzerland)May 28, 2022

Lifespan

downin worms1

1 study

Acrolein shortens lifespan in worms.
“ACR exposure (12.5-100 μM) shortened the lifespan of C. elegans.”
Model organisms12.5-100 μM
Acrolein Promotes Aging and Oxidative Stress via the Stress Response Factor DAF-16/FOXO in Caenorhabditis elegans
Foods (Basel, Switzerland)May 28, 2022

Funding

1 grant since 2021

Japan Society for the Promotion of Science

Physiological role of polyamines and search for a detoxifying medicine against its toxic metabolite acrolein
Japan Society for the Promotion of Science2021–2024

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