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AAV9-BMP10

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Outcomes

3

Oxidative phosphorylation

upin rats1

1 study

  1. AAV9-BMP10 increases oxidative phosphorylation in rats.

    “Moreover, overexpressing BMP10 stimulated mitochondrial electron transport chain complexes to generate more ATP by upregulating biogenesis makers in atrial cardiomyocytes.”

    Animalsatrial cardiomyocytes4 weeks

    BMP10 attenuates age-related atrial fibrillation susceptibility through improving mitochondrial function in atrial cardiomyocytes

    Archives of gerontology and geriatrics19 Aug 2025

More on Oxidative phosphorylation

Oxidative stress and ROS signalling

downin rats1

1 study

  1. AAV9-BMP10 decreases oxidative stress and ROS signalling in rats.

    “Overexpressing BMP10 diminished ROS production by regulating phosphorylation of STAT3 translocation into mitochondria.”

    Animalsatrial cardiomyocytes4 weeks

    BMP10 attenuates age-related atrial fibrillation susceptibility through improving mitochondrial function in atrial cardiomyocytes

    Archives of gerontology and geriatrics19 Aug 2025

More on Oxidative stress and ROS signalling

Atrial fibrosis

downin rats1

1 study

  1. AAV9-BMP10 decreases atrial fibrosis in rats.

    “Atrial fibrosis, inflammatory foci were reduced with restored electrical activity in AAV-BMP10 treated rats.”

    Animalsatrium4 weeks

    BMP10 attenuates age-related atrial fibrillation susceptibility through improving mitochondrial function in atrial cardiomyocytes

    Archives of gerontology and geriatrics19 Aug 2025

Associations

1

Atrial fibrillation

downin rats1

1 study

  1. AAV9-BMP10 lowers the risk of atrial fibrillation in rats.

    “Overexpression of BMP10 mitigated the pacing-induced AF incidence and increased conduction velocity compared to controls.”

    Animalsatrial cardiomyocytes4 weeks

    BMP10 attenuates age-related atrial fibrillation susceptibility through improving mitochondrial function in atrial cardiomyocytes

    Archives of gerontology and geriatrics19 Aug 2025

More on Atrial fibrillation

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