Aav-mediated PIM3 overexpression

Intervention

1 paper1 finding

  • 1 lab in 1 country
  • Funders: Natural Science Foundation of Fujian Province and 1 more
  • Animals1

Outcomes

1

Intervertebral disc degeneration

downin rats1

1 study
  1. Aav-mediated PIM3 overexpression protects against intervertebral disc degeneration in rats.

    “In an IDD rat model, AAV-mediated PIM3 overexpression improved ECM integrity, reduced senescence and activated the Akt pathway, mitigating disc degeneration.”

    Animalsin an IDD rat modelintervertebral disc

    PIM3 enhances nucleus pulposus cell function and extracellular matrix integrity via kinase-dependent activation of the Akt/mTOR signaling axis in intervertebral disc degeneration

    Translational research : the journal of laboratory and clinical medicine30 Dec 2025

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