4-phenylbutyrate

1. 4-phenylbutyrate improves osteoblast function in mice.

   “4-phenylbutyrate (4-PBA) has been shown to improve osteoblast function and ECM composition in OI models”

   Reviewin Col1a1+/G349C and Col1a2+/G610C osteoblasts

   OMICS Profiling Identifies Signatures of Senescence in Osteogenesis Imperfecta Osteoblasts Counteracted by 4-PBA

   Journal of cellular and molecular medicine·Apr 1, 2026

1. 4-phenylbutyrate decreases cellular senescence in mouse cells.

   “4-PBA significantly reduced senescence marker expression and decreased the number of senescent cells”

   Cellsin Col1a1+/G349C and Col1a2+/G610C osteoblasts

   OMICS Profiling Identifies Signatures of Senescence in Osteogenesis Imperfecta Osteoblasts Counteracted by 4-PBA

   Journal of cellular and molecular medicine·Apr 1, 2026

More on Cellular senescence

1. 4-phenylbutyrate decreases senescence-associated secretory phenotype (SASP) in mouse cells.

   “senescence-associated proteins were absent from the secretome following 4-PBA treatment”

   Cellsin Col1a1+/G349C and Col1a2+/G610C osteoblasts

   OMICS Profiling Identifies Signatures of Senescence in Osteogenesis Imperfecta Osteoblasts Counteracted by 4-PBA

   Journal of cellular and molecular medicine·Apr 1, 2026

More on Senescence-associated secretory phenotype (SASP)

1. 4-phenylbutyrate has no effect on PRDX4 in mice.

   “it did not restore PRDX4 content in aged mice”

   Animalsheartmales

   Endoplasmic reticulum stress and alterations of peroxiredoxins in aged hearts

   Mechanisms of ageing and development·Sep 1, 2023

More on PRDX4

1. 4-phenylbutyrate increases PRDX3 in mice.

   “While 4-PBA treatment improved PRDX3 content in aged hearts”

   Animalsheartmales

   Endoplasmic reticulum stress and alterations of peroxiredoxins in aged hearts

   Mechanisms of ageing and development·Sep 1, 2023

More on PRDX3

1. 4-phenylbutyrate decreases oxidative stress and ROS signaling in mice.

   “treatment with 4-PBA to attenuate ER stress reduced oxidative stress in aged hearts”

   Animalsheartmales

   Endoplasmic reticulum stress and alterations of peroxiredoxins in aged hearts

   Mechanisms of ageing and development·Sep 1, 2023

More on Oxidative stress and ROS signaling

1. 4-phenylbutyrate decreases monocyte migration in mouse cells.

   “Administration of 4PBA attenuated the increased ER stress and proinflammatory responses from stretch and/or age and significantly reduced monocyte migration to ATII conditioned media.”

   CellsMigration to ATII conditioned media after 4PBA treatmentmonocyte

   Inflammation and Monocyte Recruitment due to Aging and Mechanical Stretch in Alveolar Epithelium are Inhibited by the Molecular Chaperone 4-phenylbutyrate

   Cellular and molecular bioengineering·Jun 19, 2018

1. 4-phenylbutyrate decreases inflammation in mouse cells.

   “Administration of 4PBA attenuated the increased ER stress and proinflammatory responses from stretch and/or age”

   CellsStretch and/or agetype II alveolar epithelial cell

   Inflammation and Monocyte Recruitment due to Aging and Mechanical Stretch in Alveolar Epithelium are Inhibited by the Molecular Chaperone 4-phenylbutyrate

   Cellular and molecular bioengineering·Jun 19, 2018

More on Inflammation

1. 4-phenylbutyrate decreases ER unfolded protein response in mouse cells.

   “Administration of 4PBA attenuated the increased ER stress and proinflammatory responses from stretch and/or age”

   CellsStretch and/or agetype II alveolar epithelial cell

   Inflammation and Monocyte Recruitment due to Aging and Mechanical Stretch in Alveolar Epithelium are Inhibited by the Molecular Chaperone 4-phenylbutyrate

   Cellular and molecular bioengineering·Jun 19, 2018

More on ER unfolded protein response