(3r)-1,7-diphenyl-(4e,6e)-4,6-heptadien-3-ol

1. (3r)-1,7-diphenyl-(4e,6e)-4,6-heptadien-3-ol increases stem cell differentiation in human cells.

   “DPHD promoted osteogenic differentiation, as shown by increased ALP activity, calcium deposition, and upregulation of osteogenic marker genes”

   Cellsduring ex vivo expansion and differentiation2.5-5 μM

   DPHD from Curcuma comosa Enhances the Expansion and Osteogenic Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells While Attenuating Senescence

   ACS omega·18 May 2026

More on Stem cell differentiation

1. (3r)-1,7-diphenyl-(4e,6e)-4,6-heptadien-3-ol decreases senescence-associated secretory phenotype (SASP) in human cells.

   “DPHD suppressed the secretion of cytokines associated with the Senescence-Associated Secretory Phenotype (SASP), including IL-1β, IL-6, and MCP-1”

   Cells2.5-5 μM

   DPHD from Curcuma comosa Enhances the Expansion and Osteogenic Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells While Attenuating Senescence

   ACS omega·18 May 2026

More on Senescence-associated secretory phenotype (SASP)

1. (3r)-1,7-diphenyl-(4e,6e)-4,6-heptadien-3-ol decreases cellular senescence in human cells.

   “DPHD significantly reduced senescence-associated β-galactosidase activity and reduced the expression levels of the cell cycle regulators p16 and p21”

   Cells2.5-5 μM

   DPHD from Curcuma comosa Enhances the Expansion and Osteogenic Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells While Attenuating Senescence

   ACS omega·18 May 2026

More on Cellular senescence