15-deoxy-delta-12,14-prostaglandin J2
- 1 lab in 2 countries
- Funders: Science and Engineering Research Board and 3 more
- Cells4
Outcomes
3MAPK/ERK signalling
upin cells2upin human cells1upin mouse cells1
4 studies
MAPK/ERK signalling
upin cells2upin human cells1upin mouse cells1
15-deoxy-delta-12,14-prostaglandin J2 activates MAPK/ERK signalling in mouse cells.
“We further show that this lipid post-translationally modifies Cys184 of HRas in C2C12 mouse skeletal myoblasts, causing a reduction in the localization of HRas to the Golgi, increased HRas binding to Ras Binding Domain (RBD) of RAF Kinase (RAF-RBD), and activation of cellular Mitogen Activated Protein (MAP) kinase-Extracellular Signal Regulated Kinase (Erk) signaling (but not the Akt signaling).”
Cellsskeletal muscle
eLifeAug 28, 2024
15-deoxy-delta-12,14-prostaglandin J2 activates MAPK/ERK signalling in human cells.
“activation of cellular MAPK-Erk signaling (but not the Akt signaling)”
Cellsskeletal muscle
eLifeJun 21, 2024Preprint
15-deoxy-delta-12,14-prostaglandin J2 activates MAPK/ERK signalling in cells.
“We further show that this lipid post-translationally modifies Cys184 of HRas in skeletal muscle cells, causing a reduction in the localization of HRas to the Golgi, increased HRas binding to RAF RBD, and activation of cellular MAPK-Erk signaling”
Cellsin skeletal muscle cells
eLifeMar 1, 2024Preprint
15-deoxy-delta-12,14-prostaglandin J2 activates MAPK/ERK signalling in cells.
“We further show that this lipid post-translationally modifies Cys184 of HRas in skeletal muscle cells, causing a reduction in the localization of HRas to the Golgi, increased HRas binding to RAF RBD, and activation of cellular MAPK-Erk signaling”
Cellsskeletal muscle
bioRxiv (Cold Spring Harbor Laboratory)Dec 24, 2023Preprint
Myoblast fusion
downin cells1downin mouse cells1
2 studies
Myoblast fusion
downin cells1downin mouse cells1
15-deoxy-delta-12,14-prostaglandin J2 decreases myoblast fusion in mouse cells.
“Treatment of skeletal muscle myoblasts with the conditioned medium from these senescent cells inhibits myoblast fusion during differentiation.”
Cellsconditioned medium from Doxo-induced senescent cellsskeletal muscle
eLifeAug 28, 2024
15-deoxy-delta-12,14-prostaglandin J2 inhibits myoblast fusion in cells.
“Treatment of skeletal muscle myoblasts with the conditioned medium from these senescent cells inhibits myoblast fusion during differentiation.”
Cellsconditioned medium from doxorubicin-induced senescent cells
eLifeMar 1, 2024Preprint
Muscle differentiation
downin cells2
2 studies
Muscle differentiation
downin cells2
15-deoxy-delta-12,14-prostaglandin J2 inhibits muscle differentiation in cells.
“Mutating C184 of HRas prevents the ability of 15d-PGJ2 to inhibit the differentiation of muscle cells and control the activity of HRas.”
Cellsvia Cys184 modificationskeletal muscle
eLifeMar 1, 2024Preprint
15-deoxy-delta-12,14-prostaglandin J2 inhibits muscle differentiation in cells.
“Mutating C184 of HRas prevents the ability of 15d- PGJ 2 to inhibit the differentiation of muscle cells”
CellsC184 mutation of HRas prevents inhibition of muscle differentiation by 15d-PGJ2skeletal muscle
bioRxiv (Cold Spring Harbor Laboratory)Dec 24, 2023Preprint